Moving Lipids, by the Numbers.

Abstract

Lipid trafficking in eukaryotic cells can follow vesicular and non-vesicular pathways (Antonny et al., 2018). However, some organelles do rely exclusively on non-vesicular trafficking to obtain or distribute some of the lipids essential to their functions and biogenesis. In the past decades membrane contact sites between organelles have emerged as hubs for the non-vesicular trafficking of lipids, highlighting the importance of lipid transfer proteins (LTPs), a large functional class of structurally diverse proteins involved in this process (Egea, 2021).