Seroprevalence of Covid-19 infection among healthcare workers: A study from a tertiary care hospital in the National Capital Region of India.

IF 0.4 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL National Medical Journal of India Pub Date : 2022-07-01 DOI:10.25259/NMJI_345_21
Sushila Kataria, Rashmi Phogat, Pooja Sharma, Vikas Deswal, Sazid Alam, Manish Singh, Kuldeep Kumar, Vaibhav Gupta, Padam Singh, Rohit Dutt, Smita Sarma, Renu Saxena, Naresh Trehan
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Abstract

Background Seroprevalence studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can provide information on the target populations for vaccination. We aimed to evaluate the seroprevalence among healthcare workers (HCWs) at our tertiary care institution and to identify parameters that may affect it. Method We assessed seroprevalence of SARS-CoV-2 by the chemiluminescence immunoassay test among 3258 HCW in our hospital and evaluated as per gender, age, their previous Covid-19 diagnosis, role in hospital and type/risk of exposure. Results Of 3258 participants, 46.2% (95% CI 44.4%- 47.9%) were positive for SARS-CoV-2 IgG antibodies (i.e. IgG ≥15 AU/ml). Higher seroprevalence was seen in non-clinical HCWs (50.2%) than in clinical HCWs (41.4%, p=0.0001). Furthermore, people with a history of Covid-19 were found to have significantly higher antibody levels (p=0.0001). Among the HCWs, doctors and nurses had lower relative risk (RR) of acquiring Covid-19 infection (RR=0.82; 95% CI 0.76-0.89) compared to non-clinical HCWs. Conclusion Seroprevalence in HCWs at our hospital was 46.2%. Clinical HCWs had lower seroprevalence compared to non-clinical HCWs. Previous history of Covid-19 almost doubled the seropositivity, particularly in those with current infection.

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卫生保健工作者中Covid-19感染的血清流行率:来自印度国家首都地区一家三级保健医院的研究
研究严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染的血清阳性率可为疫苗接种目标人群提供信息。我们的目的是评估我们三级医疗机构的卫生保健工作者(HCWs)的血清患病率,并确定可能影响它的参数。方法采用化学发光免疫分析法对我院3258名妇幼保健人员进行SARS-CoV-2血清阳性率测定,并按性别、年龄、既往诊断、医院职务、暴露类型/暴露风险进行评估。结果3258名受试者中,46.2% (95% CI 44.4% ~ 47.9%)的SARS-CoV-2 IgG抗体阳性(即IgG≥15 AU/ml)。非临床HCWs的血清阳性率(50.2%)高于临床HCWs (41.4%, p=0.0001)。此外,有Covid-19病史的人的抗体水平明显更高(p=0.0001)。在医护人员中,医生和护士感染新冠病毒的相对风险(RR)较低(RR=0.82;95% CI 0.76-0.89)与非临床HCWs相比。结论我院HCWs患者血清患病率为46.2%。与非临床HCWs相比,临床HCWs的血清患病率较低。以往的Covid-19病史几乎使血清阳性反应增加了一倍,特别是在目前感染的患者中。
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来源期刊
National Medical Journal of India
National Medical Journal of India 医学-医学:内科
CiteScore
0.50
自引率
0.00%
发文量
171
审稿时长
>12 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of health policy and health provider training through sections on ‘Medicine and society’ and ‘Medical education’.. Articles with clinical interest and implications will be given preference.
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