Mesenchymal stem cell-derived exosomes are beneficial to suppressing inflammation and promoting autophagy in intervertebral disc degeneration.

IF 1.2 4区医学 Q3 ANATOMY & MORPHOLOGY Folia morphologica Pub Date : 2024-01-01 Epub Date: 2023-03-27 DOI:10.5603/FM.a2023.0021

Baicheng Yang, Xinming Yang

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引用次数: 0

Abstract

Background: Intervertebral disc degenerative diseases is one the main causes of lumbago, and its main pathological mechanism is intervertebral disc degeneration (IDD). As shown in previous reports, mesenchymal stem cell (MSC)-exosomes can slow down or even reverse degenerated nucleus pulposus (NP) cells in IDD. Thus, we attempted to clarify the specific role of MSC-exosomes underlying IDD progression.

Materials and methods: In the present study, the harvested particles were identified as MSC-exosomes. MSC-exosomes facilitated activation of autophagy pathway in AGE-treated NP cells. MSC-exosomes repressed inflammatory response in AGE-treated NP cells. Autophagy pathway activation enhanced inflammatory response in AGE-stimulated NP cells.

Results: Mesenchymal stem cell-exosomes facilitated autophagy pathway activation and repressed inflammation in IDD rats. Autophagy inhibition exerted a protective role against inflammatory response in IDD rats.

Conclusions: In conclusion, MSC-exosomes represses inflammation via activating autophagy pathway, which provides a potential novel insight for seeking therapeutic plans of IDD.

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间充质干细胞衍生的外泌体有利于抑制炎症和促进椎间盘变性中的自噬。

背景：椎间盘退行性疾病是导致腰痛的主要原因之一，其主要病理机制是椎间盘退变（IDD）。正如之前的报道所示，间充质干细胞（MSC）-外泌体可以减缓甚至逆转 IDD 中退化的髓核细胞。因此，我们试图阐明间充质干细胞外泌体在IDD进展中的特殊作用：在本研究中，收获的颗粒被鉴定为间叶干细胞外泌体。间充质干细胞外泌体促进了AGE处理的NP细胞自噬途径的激活。间充质干细胞外泌体抑制了 AGE 处理的 NP 细胞的炎症反应。自噬途径的激活增强了AGE刺激的NP细胞的炎症反应：结果：间充质干细胞外泌体促进了自噬途径的激活，抑制了IDD大鼠的炎症反应。自噬抑制对IDD大鼠的炎症反应具有保护作用：总之，间充质干细胞外泌体通过激活自噬通路抑制炎症，这为寻求IDD的治疗方案提供了潜在的新见解。

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来源期刊

Folia morphologica ANATOMY & MORPHOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

218

审稿时长

6-12 weeks

期刊介绍： "Folia Morphologica" is an official journal of the Polish Anatomical Society (a Constituent Member of European Federation for Experimental Morphology - EFEM). It contains original articles and reviews on morphology in the broadest sense (descriptive, experimental, and methodological). Papers dealing with practical application of morphological research to clinical problems may also be considered. Full-length papers as well as short research notes can be submitted. Descriptive papers dealing with non-mammals, cannot be accepted for publication with some exception.