{"title":"Evaluation of the newly synthesized linoleic acid derivative DCP-LA as a potential anti-dementia drug","authors":"Tomoyuki Nishizaki , Takeshi Kanno , Akinobu Gotoh","doi":"10.1016/j.pmu.2014.02.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p><span><span>We synthesized the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) with </span>cyclopropane rings instead of </span><em>cis</em>-double bonds. Here, we introduce DCP-LA as a novel anti-dementia drug.</p></div><div><h3>Study section and results</h3><p><span>DCP-LA selectively and directly activated protein kinase C-ε (PKCε) to enhance the activity of presynaptic α7 acetylcholine (ACh) receptors by promoting receptor translocation to the cell surface and increasing presynaptic glutamate release. This action of DCP-LA caused a long-lasting facilitation of hippocampal </span>synaptic transmission, which improved learning and memory impairments in animal models.</p></div><div><h3>Conclusion</h3><p>DCP-LA could be developed as a promising anti-dementia drug, offering new hope for treating dementias including Alzheimer disease.</p></div>","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 28-34"},"PeriodicalIF":0.0000,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.02.002","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized Medicine Universe","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2186495014000042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Purpose
We synthesized the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) with cyclopropane rings instead of cis-double bonds. Here, we introduce DCP-LA as a novel anti-dementia drug.
Study section and results
DCP-LA selectively and directly activated protein kinase C-ε (PKCε) to enhance the activity of presynaptic α7 acetylcholine (ACh) receptors by promoting receptor translocation to the cell surface and increasing presynaptic glutamate release. This action of DCP-LA caused a long-lasting facilitation of hippocampal synaptic transmission, which improved learning and memory impairments in animal models.
Conclusion
DCP-LA could be developed as a promising anti-dementia drug, offering new hope for treating dementias including Alzheimer disease.
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