Clinicopathological features of CD5-positive splenic marginal zone lymphoma.

IF 2.5 4区医学 Q2 PATHOLOGY Journal of Clinical Pathology Pub Date : 2024-05-17 DOI:10.1136/jcp-2022-208603

Yunling Li, Guannan Wang, Enjie Liu, Dandan Zhang, Yanping Zhang, Xiangyu Jian, Wugan Zhao, Wencai Li

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Abstract

Aims: To investigate the clinicopathological features, immunophenotypes and differential diagnosis of CD5-positive splenic marginal zone lymphoma (SMZL).

Methods: We retrospectively analysed 16 CD5-positive cases of SMZL. Assess their clinicopathological features and survival outcomes to evaluate their similarities and differences with a control group of 25 CD5-negative cases of SMZL.

Results: Compared with CD5-negative patients, CD5-positive SMZL tends to be more prone to B symptoms, peripheral lymphadenopathy and extranodal infiltration, high Ann Arbor stage, high International Prognostic Index scores, high serum lactic dehydrogenase and high rates of bone marrow involvement. The 5-year survival rate was significantly shorter than that of the CD5-negative group (52.1% and 81.8%, respectively).

Conclusions: There are many similarities between CD5-positive SMZL and classical CD5-negative SMZL in clinical presentations, morphology and immunohistochemistry, but the former may have a more aggressive clinical course with a poorer prognosis.

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CD5阳性脾边缘区淋巴瘤的临床病理特征。

目的：研究CD5阳性脾边缘区淋巴瘤（SMZL）的临床病理特征、免疫表型和鉴别诊断：我们回顾性分析了 16 例 CD5 阳性的 SMZL 病例。方法：我们回顾性分析了16例CD5阳性脾边缘区淋巴瘤（SMZL）病例，评估他们的临床病理特征和生存结果，以评价他们与对照组25例CD5阴性SMZL病例的异同：结果：与CD5阴性患者相比，CD5阳性SMZL患者更容易出现B症状、外周淋巴结病和结外浸润、高Ann Arbor分期、高国际预后指数评分、高血清乳酸脱氢酶和高骨髓受累率。5年生存率明显低于CD5阴性组（分别为52.1%和81.8%）：结论：CD5阳性SMZL与经典的CD5阴性SMZL在临床表现、形态学和免疫组化方面有许多相似之处，但前者的临床病程可能更具侵袭性，预后较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Pathology 医学-病理学

CiteScore

7.80

自引率

2.90%

发文量

113

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Pathology is a leading international journal covering all aspects of pathology. Diagnostic and research areas covered include histopathology, virology, haematology, microbiology, cytopathology, chemical pathology, molecular pathology, forensic pathology, dermatopathology, neuropathology and immunopathology. Each issue contains Reviews, Original articles, Short reports, Correspondence and more.