Correlates of long duration of untreated illness (DUI) in patients with bipolar disorder: results of an observational study.

IF 3.6 3区 医学 Q1 PSYCHIATRY Annals of General Psychiatry Pub Date : 2023-03-23 DOI:10.1186/s12991-023-00442-5
Gabriele Di Salvo, Giorgia Porceddu, Umberto Albert, Giuseppe Maina, Gianluca Rosso
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引用次数: 1

Abstract

Background: Despite a high number of studies investigating the correlation between long Duration of Untreated Illness (DUI) and poor course of Bipolar Disorder (BD), the results concerning the impact of DUI on some specific factors, such as suicidality and medical comorbidities, are still inconsistent. This cross-sectional observational study aimed at analyzing potential socio-demographic and clinical correlates of long DUI in a large cohort of real-world, well-characterized BD patients.

Methods: The socio-demographic and clinical characteristics of 897 patients with BD were collected. The sample was divided for analysis in two groups (short DUI vs long DUI) according to a DUI cutoff of 2 years. Comparisons were performed using χ2 tests for categorical variables and the Kruskal-Wallis test for continuous variables. Logistic regression (LogReg) was used to identify explanatory variables associated with DUI (dependent variable).

Results: Six-hundred and sixty patients (75.5%) presented long DUI (> 2 years) and mean DUI was 15.7 years. The LogReg analysis confirmed the association of long DUI with bipolar II disorder (p: 0.016), lower age at onset (p < 0.001), depressive predominant polarity (p: 0.018), depressive polarity onset (p < 0.001), longer duration of illness (p < 0.001), lifetime suicide attempts (p: 0.045) and current medical comorbidities (p: 0.019).

Conclusions: The present study confirms the association between long DUI and higher risk of suicide attempts in patients with BD. Moreover, an association between long DUI and higher rates of medical conditions has been found.

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双相情感障碍患者长期未治疗疾病(DUI)的相关性:一项观察性研究的结果。
背景:尽管有大量研究调查了长期未经治疗的疾病(DUI)与双相情感障碍(BD)不良病程之间的相关性,但关于DUI对一些特定因素的影响,如自杀和医疗合并症,结果仍然不一致。这项横断面观察性研究旨在分析一大群真实世界、特征明确的BD患者中长期酒后驾车的潜在社会人口学和临床相关性。方法:收集897例BD患者的社会人口学和临床特征。根据2年的酒后驾车临界值,将样本分为两组进行分析(短期酒后驾车与长期酒后驾车)。使用分类变量的χ2检验和连续变量的Kruskal-Wallis检验进行比较。Logistic回归(LogReg)用于确定与DUI相关的解释变量(因变量) LogReg分析证实了长期酒后驾车与双相情感障碍II(p:0.016)、发病年龄较低(p 结论:本研究证实了长期酒后驾车与BD患者更高的自杀未遂风险之间的关系。此外,还发现了长期酒后驾驶与更高的医疗状况发生率之间的联系。
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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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