Effects of Hypertension on Alzheimer's Disease and Related Disorders.

IF 3.9 2区医学 Q1 PERIPHERAL VASCULAR DISEASE Current Hypertension Reports Pub Date : 2022-12-01 DOI:10.1007/s11906-022-01221-5

Joseph E Malone, Mohamed I Elkasaby, Alan J Lerner

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引用次数: 3

Abstract

Purpose of review: To review the pathophysiology of hypertension in Alzheimer's disease and related dementias and explore the current landscape of clinical trials involving treatment of hypertension to improve cognition.

Recent findings: Hypertension is increasingly recognized as a contributor to cognitive impairment. Clinical trials that explore blood pressure reductions with cognitive outcomes have been promising. Various antihypertensives have been evaluated in clinical trials, with growing interest in those agents that impact the renin-angiotensin-aldosterone system due to its own association with cognitive impairment. No antihypertensive agent has been found to be superior to others in reducing cognitive impairment risk or conferring neuroprotective benefits. In this review, the pathophysiology of and clinical trial data involving hypertension and dementia will be explored. Hypertension is a significant risk factor for the development of neurodegenerative dementias, and clinical trials have been overall favorable in improving cognition by reductions in blood pressure using antihypertensive agents.

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高血压对阿尔茨海默病及相关疾病的影响。

综述目的:回顾高血压在阿尔茨海默病及相关痴呆中的病理生理学，探讨高血压治疗改善认知的临床试验现状。最近的研究发现:高血压越来越被认为是认知障碍的一个因素。探索血压降低与认知结果的临床试验一直很有希望。各种抗高血压药物已经在临床试验中进行了评估，人们对那些影响肾素-血管紧张素-醛固酮系统的药物越来越感兴趣，因为它本身与认知障碍有关。没有发现降压药在降低认知障碍风险或赋予神经保护作用方面优于其他降压药。在这篇综述中，将探讨高血压和痴呆的病理生理学和临床试验数据。高血压是神经退行性痴呆发展的重要危险因素，临床试验总体上有利于通过使用降压药降低血压来改善认知。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.