A Late Presentation of COVID-19 Induced Bowel Ischemia.

Hani Michael Annabi, Darrel Dodson, Bruce Applebaum, Benjamin Clapp
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Abstract

Introduction: Infection with COVID-19 may lead to extrapulmonary pathologies secondary to the systemic inflammatory effects of the virus.

Case description: This case report discusses a 55-year-old female patient who presented with small bowel obstruction (SBO) several months after resolution of a COVID-19 infection. The patient was surgically treated with a small bowel resection, and eventually made a full recovery.

Discussion: The pathophysiology of COVID-19-induced SBO can be explained by the prolonged inflammation and coagulation activation in the bowel's vasculature system. Under these circumstances, microthrombosis occurs in the bowel's microvasculature; the affected intestinal tissue becomes ischemic and infarcted. The damaged bowel is eventually replaced with fibrotic scar tissue, thus promoting bowel stricture and subsequent obstruction.

Conclusion: COVID-19 can be responsible for both acute and chronic embolic and thrombotic events in the mesenteric vasculature, which acts as a risk factor in the manifestation of SBO.

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COVID-19诱导的肠缺血的晚期表现。
COVID-19感染可能导致继发于该病毒的全身炎症作用的肺外病变。病例描述:本病例报告讨论了一名55岁女性患者,在COVID-19感染消退几个月后出现小肠梗阻(SBO)。病人接受了手术治疗,切除了小肠,最终完全康复。讨论:新型冠状病毒引起的SBO的病理生理可以通过肠道血管系统炎症和凝血激活的延长来解释。在这种情况下,微血栓形成发生在肠道微血管;受影响的肠组织发生缺血和梗死。受损的肠最终被纤维化瘢痕组织取代,从而促进肠狭窄和随后的梗阻。结论:COVID-19可导致肠系膜血管急性和慢性栓塞和血栓形成事件,这是SBO表现的危险因素。
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