Clinical significance of Notch receptors in triple negative breast cancer.

Breast disease Pub Date : 2023-01-01 DOI:10.3233/BD-220041

Heer Shah, Mittal Mistry, Nupur Patel, Hemangini Vora

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Abstract

Background: The Notch signaling pathway is an evolutionary conserved cell signaling pathway that plays an indispensable role in essential developmental processes. Aberrant activation of Notch pathway is known to initiate wide array of diseases and cancers.

Objective: To evaluate the clinical significance of Notch receptors in Triple Negative Breast Cancer.

Methods: We evaluated the association between Notch receptors and clinicopathological parameters including disease-free survival and overall survival of one hundred TNBC patients by immunohistochemistry.

Results: Positive expression of nuclear Notch1 receptor (18%) was found be significantly correlated with positive lymph node (p = 0.009), high BR score (p = 0.02) and necrosis (p = 0.004) while cytoplasmic expression of Notch2 receptor (26%) was significantly correlated with metastasis (p = 0.05), worse DFS (p = 0.05) and poor OS (p = 0.02) in TNBC patients. Membrane (18%) and cytonuclear (3%) Notch3 expression were significantly associated with poorly differentiated tumors (p = 0.007), high BR score (p = 0.002) and necrosis (p = 0.03) respectively. However, cytoplasmic Notch3 and Notch4 expression were negatively correlated with poor prognostic factors.

Conclusions: Our data indicated that Notch receptors play a key role in promoting TNBC and mainly, Notch2 may contribute to poor prognosis of the disease. Hence, it is implicated that Notch2 may serve as a potential biomarker and therapeutic target for TNBC.

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三阴性乳腺癌中 Notch 受体的临床意义。

背景：Notch信号通路是一种进化保守的细胞信号通路，在重要的发育过程中发挥着不可或缺的作用。众所周知，Notch通路的异常激活会引发多种疾病和癌症：评估 Notch 受体在三阴性乳腺癌中的临床意义：方法：我们通过免疫组化方法评估了Notch受体与临床病理参数（包括100例TNBC患者的无病生存率和总生存率）之间的关系：结果：发现核Notch1受体（18%）的阳性表达与淋巴结阳性（p = 0.009）、BR评分高（p = 0.02）和坏死（p = 0.004）显著相关，而Notch2受体（26%）的胞浆表达与TNBC患者的转移（p = 0.05）、较差的DFS（p = 0.05）和较差的OS（p = 0.02）显著相关。膜（18%）和胞核（3%）Notch3的表达分别与肿瘤分化不良（p = 0.007）、BR评分高（p = 0.002）和坏死（p = 0.03）显著相关。然而，细胞质Notch3和Notch4的表达与不良预后因素呈负相关：我们的数据表明，Notch受体在促进TNBC的发展中起着关键作用，其中主要是Notch2可能会导致该病的不良预后。因此，Notch2可作为TNBC的潜在生物标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.