Letter to the editor regarding the review article by Yamada et al. (2021) titled "Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)".
Petra van Kesteren, Marja Pronk, Harm Heusinkveld, Mirjam Luijten, Betty Hakkert
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引用次数: 1
Abstract
comprehensive review article by Yamada et al. (2021) on a topic that is a matter of scientific debate for quite some years now: the human relevance of the mode of action (MoA) for liver tumor formation by chemicals that are activators of the constitutive androstane receptor (CAR). Following a critical analysis of currently available data concerning this topic the authors conclude that this MoA is qualitatively not plausible for humans. Their conclusion is based on a pivotal species difference in hepatocellular proliferation (a key event in CAR-mediated rodent liver tumor formation), supported by negative epidemiology data for the archetypical CAR activator phenobarbital (PB). According to the authors
期刊介绍：
Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.
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