Constructional Impairments and Their Neural Correlates in Nondemented Adults With Cerebral Autosomal-dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

IF 1.3 4区医学 Q4 BEHAVIORAL SCIENCES Cognitive and Behavioral Neurology Pub Date : 2022-12-01 DOI:10.1097/WNN.0000000000000318

Natascia De Lucia, Michele Ragno, Cristina Paci, Gabriella Cacchiò, Anna Rita Caiazzo, Sara Tiberi, Anna De Rosa, Riccardo Navarra, Massimo Caulo, Giuseppe De Michele, Luigi Trojano

{"title":"Constructional Impairments and Their Neural Correlates in Nondemented Adults With Cerebral Autosomal-dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.","authors":"Natascia De Lucia, Michele Ragno, Cristina Paci, Gabriella Cacchiò, Anna Rita Caiazzo, Sara Tiberi, Anna De Rosa, Riccardo Navarra, Massimo Caulo, Giuseppe De Michele, Luigi Trojano","doi":"10.1097/WNN.0000000000000318","DOIUrl":null,"url":null,"abstract":"Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small-vessel disease that is characterized by a wide range of neurologic and neuropsychological impairments. Constructional impairments have been reported in some cases but have never been assessed systematically.Objective: To evaluate constructional abilities and their cognitive and neural correlates in nondemented individuals with CADASIL.Method: Thirty individuals with CADASIL who were not affected by clinically relevant cognitive deterioration and 30 healthy controls (HC) underwent an extensive cognitive assessment and paper-and-pencil visuoconstructional tasks in order to detect constructional impairments. Performance on the visuoconstructional tasks was correlated with the cognitive assessment scores and with quantitative indices of regional gray matter atrophy (obtained via FreeSurfer image analysis) and white matter involvement.Results: The individuals with CADASIL achieved significantly lower scores on the cognitive assessment compared with the HC. Poor visuoconstructional abilities were observed in seven (23.3%) of the individuals with CADASIL when performing the copy drawing task and in nine (30%) when performing the Rey Complex Figure Test. Logistic regression revealed that visuoconstructional impairments were significantly associated with scores on the Frontal Assessment Battery and the Attentional Matrices Test. Morphometric results revealed that scores on the visuoconstructional tasks were related to gray matter atrophy of the left frontal lobe and right parietal lobe.Conclusion: Impairments on visuoconstructional tasks are quite common in individuals with CADASIL, even in the lack of clinically relevant cognitive deterioration, and are critically related to frontal and parietal atrophy.","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cognitive and Behavioral Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/WNN.0000000000000318","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 1

Abstract

Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small-vessel disease that is characterized by a wide range of neurologic and neuropsychological impairments. Constructional impairments have been reported in some cases but have never been assessed systematically.

Objective: To evaluate constructional abilities and their cognitive and neural correlates in nondemented individuals with CADASIL.

Method: Thirty individuals with CADASIL who were not affected by clinically relevant cognitive deterioration and 30 healthy controls (HC) underwent an extensive cognitive assessment and paper-and-pencil visuoconstructional tasks in order to detect constructional impairments. Performance on the visuoconstructional tasks was correlated with the cognitive assessment scores and with quantitative indices of regional gray matter atrophy (obtained via FreeSurfer image analysis) and white matter involvement.

Results: The individuals with CADASIL achieved significantly lower scores on the cognitive assessment compared with the HC. Poor visuoconstructional abilities were observed in seven (23.3%) of the individuals with CADASIL when performing the copy drawing task and in nine (30%) when performing the Rey Complex Figure Test. Logistic regression revealed that visuoconstructional impairments were significantly associated with scores on the Frontal Assessment Battery and the Attentional Matrices Test. Morphometric results revealed that scores on the visuoconstructional tasks were related to gray matter atrophy of the left frontal lobe and right parietal lobe.

Conclusion: Impairments on visuoconstructional tasks are quite common in individuals with CADASIL, even in the lack of clinically relevant cognitive deterioration, and are critically related to frontal and parietal atrophy.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

伴有皮质下梗死和白质脑病的大脑常染色体显性动脉病变的非痴呆成人的结构损伤及其神经相关性。

背景：伴有皮质下梗死和白质脑病的大脑常染色体显性遗传性动脉病（CADASIL）是一种单基因小血管疾病，其特征是广泛的神经和神经心理损伤。在某些情况下，曾报告过结构损伤，但从未进行过系统评估。目的：评估患有CADASIL的非痴呆患者的结构能力及其认知和神经相关性。方法：30名未受临床相关认知恶化影响的CADASIL患者和30名健康对照（HC）接受了广泛的认知评估和纸笔视觉结构任务，以检测结构减值。视觉结构任务的表现与认知评估得分以及区域灰质萎缩（通过FreeSurfer图像分析获得）和白质受累的定量指标相关。结果：与HC相比，患有CADASIL的个体在认知评估方面的得分显著较低。在进行复制绘图任务时，有7名（23.3%）CADASIL患者的视觉构造能力较差，在进行Rey复杂图形测试时，有9名（30%）患者的视觉结构能力较差。Logistic回归显示，视觉结构障碍与正面评估组和注意力矩阵测试的得分显著相关。形态计量学结果显示，视觉结构任务得分与左额叶和右顶叶灰质萎缩有关。结论：视觉结构任务障碍在CADASIL患者中非常常见，即使在没有临床相关认知恶化的情况下也是如此，并且与额顶叶萎缩密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Cognitive and Behavioral Neurology 医学-行为科学

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

>12 weeks

期刊介绍： Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.