Analisa Jia, Lisa Kuramoto, Freda M Warner, Lisa Liu, Alexandra M Williams, Annalijn Conklin, Christopher R West, Jacquelyn J Cragg
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引用次数: 0
Abstract
Context/objective: The risk for cardiovascular disease is amplified following spinal cord injury, but whether risk differs between the sexes remains unknown. Here, we evaluated sex differences in the prevalence of heart disease among individuals with spinal cord injury, and compared sex differences with able-bodied individuals.
Design: The design was a cross-sectional study. Multivariable logistic regression analysis was conducted, using inverse probability weighting to account for the sampling method and to adjust for confounders.
Setting: Canada.
Participants: Individuals who participated in the national Canadian Community Health Survey.
Interventions: Not applicable.
Outcome measures: Self-reported heart disease.
Results: Among 354 individuals with spinal cord injury, the weighted prevalence of self-reported heart disease was 22.9% in males and 8.7% in females, with an inverse-probability weighted odds ratio of 3.44 (95% CI 1.70-6.95) for males versus females. Among 60,605 able-bodied individuals, the prevalence of self-reported heart disease was 5.8% in males and 4.0% in females, with an inverse probability weighted odds ratio of 1.62 (95% CI 1.50-1.75) for males versus females. The effect of male sex on increasing heart disease prevalence was about two times higher among individuals with spinal cord injury than able-bodied individuals (relative difference in inverse probability weighted odds ratios = 2.12, 95% CI 1.08-4.51).
Conclusion: Males with spinal cord injury exhibit a significantly higher prevalence of heart disease, compared with females with spinal cord injury. Moreover, relative to able-bodied individuals, spinal cord injury amplifies sex-related differences in heart disease. Overall, this work will inform targeted cardiovascular prevention strategies, and may also inform a better understanding of cardiovascular disease progression in both able-bodied and individuals with spinal cord injury.
背景/目的：脊髓损伤后患心血管疾病的风险会增大，但不同性别之间的风险是否存在差异仍是未知数。在此，我们评估了脊髓损伤患者心脏病发病率的性别差异，并将性别差异与健全人进行了比较：设计：这是一项横断面研究。采用反概率加权法进行多变量逻辑回归分析，以考虑抽样方法并调整混杂因素：地点：加拿大：干预措施：不适用：结果测量结果结果：在354名脊髓损伤患者中，男性和女性自我报告的心脏病加权患病率分别为22.9%和8.7%，男性和女性的反概率加权几率比为3.44（95% CI 1.70-6.95）。在 60 605 名健全人中，男性自我报告的心脏病患病率为 5.8%，女性为 4.0%，男性与女性的反概率加权几率比为 1.62（95% CI 1.50-1.75）。在脊髓损伤患者中，男性性别对心脏病患病率增加的影响大约是健全人的两倍（逆概率加权几率比的相对差异=2.12，95% CI 1.08-4.51）：结论：与女性脊髓损伤者相比，男性脊髓损伤者的心脏病发病率明显更高。此外，与健全人相比，脊髓损伤扩大了心脏病的性别差异。总之，这项工作将为有针对性的心血管疾病预防策略提供信息，也可帮助人们更好地了解健全人和脊髓损伤者的心血管疾病进展情况。
期刊介绍：
For more than three decades, The Journal of Spinal Cord Medicine has reflected the evolution of the field of spinal cord medicine. From its inception as a newsletter for physicians striving to provide the best of care, JSCM has matured into an international journal that serves professionals from all disciplines—medicine, nursing, therapy, engineering, psychology and social work.
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