Synthesis of trifluoromethyl formazans by reaction of trifluoromethyl N-acylhydrazones/N-Aryl hydrazones and aryldiazonium tetrafluoroborates

IF 1.7 4区 化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI:10.1016/j.jfluchem.2023.110211
Ke-Hu Wang , Chang Bian , Xiuwen Liang , Wenjing Luo , Junjiao Wang , Danfeng Huang , Yulai Hu
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Abstract

An efficient direct azo-coupling reaction of trifluoromethyl N-acylhydrazones/N-aryl hydrazones with aryldiazonium tetrafluoroborates was developed for the synthesis of various trifluoromethyl formazans. This protocol has the advantages of mild reaction condition, broad substrate scope and easy operation, which extends the application of trifluoromethyl N-acylhydrazones/N-aryl hydrazones as versatile trifluoromethyl building blocks in organic synthesis.

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三氟甲基n -酰基腙/ n -芳基腙与芳基重氮四氟硼酸盐反应合成三氟甲基甲氮酰胺
采用三氟甲基n -酰基腙/ n -芳基腙与四氟硼酸芳基重氮铵进行了高效的直接偶氮偶联反应,合成了多种三氟甲基甲酰胺。该方案具有反应条件温和、底物范围广、操作简便等优点,扩展了三氟甲基n -酰基腙/ n -芳基腙作为多功能三氟甲基基块在有机合成中的应用。
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来源期刊
Journal of Fluorine Chemistry
Journal of Fluorine Chemistry 化学-无机化学与核化学
CiteScore
3.80
自引率
10.50%
发文量
99
审稿时长
33 days
期刊介绍: The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.
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