Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2023-03-15 DOI:10.5937/jomb0-39570

Jingxuan Fu, Yidan Wang, Yunyi Liu, Qinfei Song, Jingrong Cao, Wang Peichang

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Abstract

Background: This study aims to establish reference intervals (RIs) for thyroid hormones in the elderly population and analyze their influence on the prevalence of subclinical hypothyroidism.

Methods: Thyroid hormone records of subjects who underwent routine health checkup at our hospital between 2018 and 2020 were analyzed. Thyroid stimulating hormone (TSH), total triiodothyronine, total thyroxine, free triiodothyronine (FT3), and free thyroxine (FT4) levels were compared between young and elderly subjects. Thresholds of these thyroid hormones were established for elderly subjects.

Results: A total of 22,207 subjects were included. Of them, 2,254 (10.15%) were aged ≥ 65 years. Elderly subjects had higher TSH, and lower FT3 and FT4 levels when compared with young subjects. In the elderly group, the RIs for TSH, FT3 and FT4 were 0.55-5.14 mIU/L, 3.68-5.47 pmol/L, and 12.00-19.87 pmol/L, respectively. The age and sex specific RIs for TSH were 0.56-5.07 mIU/L for men and 0.51-5.25 mIU/L for women. With whole-group RIs and age and sex-specific RIs for elderly people, the prevalence of subclinical hypothyroidism was 9.83% and 6.29% (p < 0.001), respectively.

Conclusions: Elderly individuals had higher TSH levels than young individuals. Our study indicated that establishing specific RIs for elderly individuals is needed. This has implications for the diagnosis and management of subclinical hypothyroidism in the elderly population.

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老年人甲状腺激素参考区间及其对亚临床甲状腺功能减退诊断的影响。

背景:本研究旨在建立老年人甲状腺激素参考区间(RIs)，并分析其对亚临床甲状腺功能减退患病率的影响。方法:对2018 - 2020年在我院进行常规健康检查的受试者的甲状腺激素记录进行分析。比较青年和老年受试者的促甲状腺激素(TSH)、总三碘甲状腺原氨酸、总甲状腺素、游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平。这些甲状腺激素的阈值是为老年人设定的。结果:共纳入22,207名受试者。其中年龄≥65岁2254例(10.15%)。与年轻受试者相比，老年受试者的TSH较高，FT3和FT4水平较低。老年组TSH、FT3、FT4的RIs分别为0.55 ~ 5.14 mIU/L、3.68 ~ 5.47 pmol/L、12.00 ~ 19.87 pmol/L。男性TSH的年龄和性别特异性RIs为0.56-5.07 mIU/L，女性为0.51-5.25 mIU/L。在全组RIs和年龄、性别特异性RIs中，老年人亚临床甲状腺功能减退的患病率分别为9.83%和6.29% (p < 0.001)。结论:老年人TSH水平高于年轻人。我们的研究表明，需要为老年人建立特定的RIs。这对老年亚临床甲状腺功能减退症的诊断和治疗具有指导意义。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.