Prevalence and patterns of dyslipidemia among lipid-lowering drug-naïve patients with type 2 diabetes mellitus – A countrywide study in Bangladesh

Q3 Medicine Endocrine and Metabolic Science Pub Date : 2023-11-01 DOI:10.1016/j.endmts.2023.100152

A.B.M. Kamrul-Hasan , Muhammad Shah Alam , Nusrat Zarin , Md Ahamedul Kabir , Abu Jar Gaffar , Md Firoj Hossain , Samir Kumar Talukder , Ahmed Ifrad Bin Raunak , Md Masud Un Nabi , Md Asaduzzaman , Mohammad Jahid Hasan , Md. Abdullah Saeed Khan , Shahjada Selim

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Abstract

Background

Dyslipidemia is a major risk factor for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). This countrywide study explored the prevalence and patterns of dyslipidemia among patients with T2DM who were not taking lipid-lowering drugs (LLD).

Methods

This cross-sectional study included 2241 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. Lipid profiles were measured in fasting blood samples using automatic analyzers. Data were analyzed using Stata 17 (Stata Corp LLC, TX, USA).

Results

2241 patients were investigated; their mean age was 46.27 (±11.27, SD) years, and 57.16 % were women. Overall, the prevalence of dyslipidemia was 96.83 %. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and triglyceride (TG) were high in 42.88 %, 63.54 %, and 71.40 % of patients, respectively; high-density lipoprotein cholesterol (HDLC) was low in 77.60 %. Mixed dyslipidemia (including raised TC, LDLC, TG, and low HDLC) was the most prevalent (24.05 %) type. Being woman (adjusted OR: 5.63, 95%CI: 3.07–11.1) and uncontrolled diabetes (HbA1c <7 %) (adjusted OR: 2.64, 95%CI: 1.54–4.52) were independently associated with dyslipidemia. Dyslipidemia was associated with microvascular complications of diabetes.

Conclusion

Dyslipidemia is a highly prevalent abnormality among LLD-naïve T2DM patients in Bangladesh. Early detection and prompt management are required to prevent complications arising from dyslipidemia.

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降脂drug-naïve 2型糖尿病患者血脂异常的患病率和模式-孟加拉国的一项全国性研究

背景:血脂异常是2型糖尿病(T2DM)患者发生心血管疾病的主要危险因素。这项全国性的研究探讨了未服用降脂药物(LLD)的2型糖尿病患者血脂异常的患病率和模式。该横断面研究包括2241名T2DM患者，于2021年1月至12月在孟加拉国的几个内分泌门诊就诊。使用自动分析仪测量空腹血液样本的脂质谱。数据分析使用Stata 17 (Stata Corp LLC, TX, USA)。结果共调查2241例患者;平均年龄46.27(±11.27,SD)岁，女性占57.16%。总体而言，血脂异常的患病率为96.83%。总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)和甘油三酯(TG)分别为42.88%、63.54%和71.40%;高密度脂蛋白胆固醇(HDLC)低，占77.60%。混合型血脂异常(包括高TC、低ldl、TG和低hdl)最为常见(24.05%)。女性(校正OR: 5.63, 95%CI: 3.07-11.1)和未控制的糖尿病(HbA1c < 7%)(校正OR: 2.64, 95%CI: 1.54-4.52)与血脂异常独立相关。血脂异常与糖尿病的微血管并发症有关。结论血脂异常是孟加拉国LLD-naïve T2DM患者中非常普遍的异常。需要及早发现和及时处理，以防止血脂异常引起的并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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