Increased insulin resistance with reduced beta cell function in recovered COVID-19 Ghanaians

Q3 Medicine Endocrine and Metabolic Science Pub Date : 2023-10-29 DOI:10.1016/j.endmts.2023.100150

Richard Kujo Adatsi , Ansumana Sandy Bockarie , Leonard Derkyi-Kwarteng , Faustina Pappoe , Paul Nsiah , Kwabena Dankwa , Samuel Acquah

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Abstract

Aim

This study compares levels of insulin resistance and beta-cell function and their relationship with liver enzymes in recovered COVID-19 participants and their uninfected counterparts in a cross-sectional study design in the Tamale metropolis of Ghana.

Methods

Biochemical indices for liver function, lipid metabolism, inflammation and oxidative stress were assessed under fasting state in 110 recovered COVID-19 and 116 uninfected participants. The homeostatic model assessment of insulin resistance (HOMA-IR) and the triglyceride-glucose index (TyG) were employed for the assessment of insulin resistance.

Results

Recovered COVID-19 participants presented lower (P < 0.05) levels of fasting glucose, insulin, alkaline phosphatase, creatinine and beta-cell function but higher (P < 0.05) levels of alanine/aspartate transferase, total bilirubin, direct bilirubin, total cholesterol, high-density lipoprotein cholesterol and HOMA-IR than their uninfected counterparts. The mean levels of the remaining indices were comparable (P > 0.05) between the study groups. Prevalence of insulin resistance ranged from 61 % (71/116) to 81 % (89/110) for the uninfected and recovered COVID-19 participants respectively. Selected liver enzymes associated with HOMA-IR and TyG.

Conclusion

The risk of developing type 2 diabetes mellitus appears higher in recovered COVID-19 participants than their uninfected counterparts despite the high prevalence of insulin resistance in both groups.

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康复的COVID-19加纳人胰岛素抵抗增加，β细胞功能降低

目的:本研究通过横断面研究设计，比较了加纳塔马利市康复的COVID-19参与者和未感染的参与者的胰岛素抵抗和β细胞功能水平及其与肝酶的关系。方法对110例新冠肺炎康复者和116例未感染者在空腹状态下进行肝功能、脂质代谢、炎症和氧化应激等生化指标的检测。采用胰岛素抵抗稳态模型评估(HOMA-IR)和甘油三酯-葡萄糖指数(TyG)评估胰岛素抵抗。结果康复的COVID-19患者出现较低的(P <0.05)空腹血糖、胰岛素、碱性磷酸酶、肌酐和β细胞功能水平，但高于对照组(P <0.05)丙氨酸/天冬氨酸转移酶、总胆红素、直接胆红素、总胆固醇、高密度脂蛋白胆固醇和HOMA-IR水平高于未感染的对照组。其余指标的平均水平具有可比性(P >0.05)。未感染和康复的COVID-19参与者的胰岛素抵抗患病率分别为61%(71/116)至81%(89/110)。选择与HOMA-IR和TyG相关的肝酶。结论康复的COVID-19患者发生2型糖尿病的风险高于未感染的患者，尽管两组患者均存在较高的胰岛素抵抗患病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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