Nathaniel G. Garrison , Stefan Andrew Harry , Maxime A. Siegler , Guilherme Cariello , Rodrigo A. Cormanich , Thomas Lectka
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引用次数: 1
Abstract
In this communication, we explore a unique molecule that exhibits a substantial interaction between a CF2H group and a CF group. In medicinal chemistry, CF2H groups are known as weak hydrogen bond donors, and CF groups as weak H-bond acceptors. Seldom are they paired up together in an array such that their unique properties can be examined. In this case, we establish that along with an attractive hydrogen bonding interaction, an n → σ* component anchors the interactions. A unique combination of steric and hyperconjugative effects ‘switches’ the interaction away from previously reported dominant tetrel-type bonding in the case of a CH2F and CF interation towards an unusualy complex hybrid interaction. Crystallographic, computational, and spectroscopic studies illuminate the problem.
期刊介绍：
The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature.
For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.
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