Molecular Mechanisms of Glaucoma Pathogenesis with Implications to Caveolin Adaptor Protein and Caveolin-Shp2 Axis.

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Aging and Disease Pub Date : 2024-10-01 DOI:10.14336/AD.2023.1012
Mojdeh Abbasi, Vivek Gupta, Nitin Chitranshi, Petros Moustardas, Reza Ranjbaran, Stuart L Graham
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Abstract

Glaucoma is a common retinal disorder characterized by progressive optic nerve damage, resulting in visual impairment and potential blindness. Elevated intraocular pressure (IOP) is a major risk factor, but some patients still experience disease progression despite IOP-lowering treatments. Genome-wide association studies have linked variations in the Caveolin1/2 (CAV-1/2) gene loci to glaucoma risk. Cav-1, a key protein in caveolae membrane invaginations, is involved in signaling pathways and its absence impairs retinal function. Recent research suggests that Cav-1 is implicated in modulating the BDNF/TrkB signaling pathway in retinal ganglion cells, which plays a critical role in retinal ganglion cell (RGC) health and protection against apoptosis. Understanding the interplay between these proteins could shed light on glaucoma pathogenesis and provide potential therapeutic targets.

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青光眼发病的分子机制与小窝蛋白衔接蛋白和小窝蛋白- shp2轴的关系。
青光眼是一种常见的视网膜疾病,其特征是进行性视神经损伤,导致视力障碍和潜在的失明。眼压升高是主要的危险因素,但尽管进行了降低眼压的治疗,一些患者仍会出现疾病进展。全基因组关联研究已经将CAV-1/2基因位点的变异与青光眼风险联系起来。Cav-1是小泡膜内陷的关键蛋白,参与信号通路,其缺失会损害视网膜功能。最近的研究表明,Cav-1参与调节视网膜神经节细胞BDNF/TrkB信号通路,在视网膜神经节细胞(RGC)健康和保护细胞凋亡中起关键作用。了解这些蛋白之间的相互作用有助于揭示青光眼的发病机制并提供潜在的治疗靶点。
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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
期刊最新文献
Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies. Coupling of Alzheimer's Disease Genetic Risk Factors with Viral Susceptibility and Inflammation. Molecular Mechanisms of Glaucoma Pathogenesis with Implications to Caveolin Adaptor Protein and Caveolin-Shp2 Axis. Aging and Sex Differences in Brain Volume and Cerebral Blood Flow. Brain Insulin Signaling is Associated with Late-Life Cognitive Decline.
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