Impact of Chronic Moderate Exercise on Immune Cells and Cytokine Levels in Rats: Focus on the Endocannabinergic Pathway.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2024-01-01 Epub Date: 2023-11-14 DOI:10.1089/jir.2023.0120
Salvador Valencia-Sánchez, Karen Elizabeth Nava-Castro, Claudia Angélica Garay-Canales, Víctor Hugo Del Río-Araiza, Jorge Morales-Montor
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Abstract

Although the modulation of immunity by exercise has been a long-studied paradigm, the molecular pathways connecting the two are still not fully understood. Regular moderate aerobic exercise is associated with improved health and directly impacts the immune system by changing the proportion of cell subpopulations, their function, and interleukin production. The endocannabinoid system has gained importance as an immune modulator, affected by moderate aerobic promoting the production of endocannabinoids, which are ligands of the cannabinoid receptors (CBRs) expressed on the surface of all immune cells. Our group previously reported a reduction of lymphocytic populations in the spleen of chronically exercised rats, accompanied by an increase in CBR expression. Given the complex and compartmentalized nature of the immune system, we decided to study the effects of chronic exercise on the proportion of peripheral blood mononuclear cells, serum interleukins, and the expression of CBRs on these cells. Overall, our results indicate that chronic exercise decreases the proportion of T helper and Tγδ cells but increases the expression of cannabinoids (CBR1) on T helper and natural killer cells, and the production of interleukins, including IL-1β, interferon-gamma, tumor necrosis factor-alpha, IL-10, and IL-4, suggesting higher reactivity and efficiency from the immune system conferred by exercise.

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慢性适度运动对大鼠免疫细胞和细胞因子水平的影响:内源性大麻素途径的研究
虽然运动对免疫的调节已经被研究了很长时间,但连接两者的分子途径仍然没有完全被理解。定期适度的有氧运动与改善健康有关,并通过改变细胞亚群的比例、功能和白细胞介素的产生直接影响免疫系统。内源性大麻素系统作为一种重要的免疫调节剂,受到适度有氧运动的影响,促进内源性大麻素的产生,内源性大麻素是在所有免疫细胞表面表达的大麻素受体(CBRs)的配体。本研究小组之前报道了长期运动大鼠脾脏淋巴细胞数量减少,并伴有CBR表达增加。鉴于免疫系统的复杂性和区隔性,我们决定研究慢性运动对外周血单个核细胞比例、血清白细胞介素和这些细胞上cbr表达的影响。总体而言,我们的研究结果表明,慢性运动降低了T辅助细胞和Tγδ细胞的比例,但增加了大麻素(CBR1)在T辅助细胞和自然杀伤细胞上的表达,以及白细胞介素(包括IL-1β、干扰素γ、肿瘤坏死因子α、IL-10和IL-4)的产生,表明运动赋予免疫系统更高的反应性和效率。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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