Kangkang Huang, Yunlai Liang, Kun Wang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi
{"title":"Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired.","authors":"Kangkang Huang, Yunlai Liang, Kun Wang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi","doi":"10.3389/fcdhc.2022.831128","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Renin-angiotensin-aldosterone system plays important roles in the development of diabetic nephropathy (DN), and angiotensin converting enzyme (ACE) is the key factor in the process from angiotensin I to angiotensin II, but the variation and roles of serum ACE in DN patients are still unclear.</p><p><strong>Methods: </strong>Forty-four type 2 diabetes mellitus (T2DM) patients, 75 DN patients, and 36 age-gender-matched healthy volunteers were recruited who attended Xiangya Hospital of Central South University in this case control study. Serum ACE levels and other indexes were tested with commercial kit.</p><p><strong>Results: </strong>ACE levels in DN were significantly higher than T2DM and controls (F = 9.66, <i>P</i> < 0.001). Serum ACE levels significantly correlated with UmALB (r = 0.3650, <i>P</i> < 0.001), BUN (r = 0.3102, <i>P</i> < 0.001), HbA1c (r = 0.2046, <i>P</i> = 0.0221), ACR (r = 0.4187, <i>P</i> < 0.001), ALB (r = -0.1885, <i>P</i> = 0.0192), and eGFR (r = -0.3955, P < 0.001), and we got an equation that Y = 2.839 + 0.648X<sub>1</sub> + 2.001X<sub>2</sub> + 0.003X<sub>3</sub> - 6.637X<sub>4</sub> +0.416X<sub>5</sub> - 0.134X<sub>6</sub> (Y: ACE; X<sub>1</sub>: BUN; X<sub>2</sub>: HbA1C; X<sub>3</sub>: UmALB; X<sub>4</sub>: gender; X<sub>5</sub>: ALB; X<sub>6</sub>: eGFR, R<sup>2</sup> = 0.655). When DN patients were divided into advanced-stage and early-stage with or without DR, ACE levels would increase when early-stage DN develops into advanced-stage or companied with DR.</p><p><strong>Conclusion: </strong>Elevated serum ACE levels may hint DN progression or retina impaired of DN patients.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012155/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in clinical diabetes and healthcare","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fcdhc.2022.831128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Objectives: Renin-angiotensin-aldosterone system plays important roles in the development of diabetic nephropathy (DN), and angiotensin converting enzyme (ACE) is the key factor in the process from angiotensin I to angiotensin II, but the variation and roles of serum ACE in DN patients are still unclear.
Methods: Forty-four type 2 diabetes mellitus (T2DM) patients, 75 DN patients, and 36 age-gender-matched healthy volunteers were recruited who attended Xiangya Hospital of Central South University in this case control study. Serum ACE levels and other indexes were tested with commercial kit.
Results: ACE levels in DN were significantly higher than T2DM and controls (F = 9.66, P < 0.001). Serum ACE levels significantly correlated with UmALB (r = 0.3650, P < 0.001), BUN (r = 0.3102, P < 0.001), HbA1c (r = 0.2046, P = 0.0221), ACR (r = 0.4187, P < 0.001), ALB (r = -0.1885, P = 0.0192), and eGFR (r = -0.3955, P < 0.001), and we got an equation that Y = 2.839 + 0.648X1 + 2.001X2 + 0.003X3 - 6.637X4 +0.416X5 - 0.134X6 (Y: ACE; X1: BUN; X2: HbA1C; X3: UmALB; X4: gender; X5: ALB; X6: eGFR, R2 = 0.655). When DN patients were divided into advanced-stage and early-stage with or without DR, ACE levels would increase when early-stage DN develops into advanced-stage or companied with DR.
Conclusion: Elevated serum ACE levels may hint DN progression or retina impaired of DN patients.