The Influence of Part-Time Occlusion Therapy on Control of Intermittent Exotropia: A Meta-Analysis of Randomized Controlled Trials.

IF 2 4区医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2023-03-30 DOI:10.1159/000530059

Desheng Song, Mengting Yang, Jing Qian, Zhijun Chen, Qing Zhou, Juan Chen

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Abstract

Background: Intermittent exotropia is the most prevalent subtype of exotropia in children. Part-time occlusion (PTO) as an anti-suppression therapy was applied for nonsurgical management of intermittent exotropia.

Objective: The aim of the study was to compare the effectiveness of PTO therapy and observation in the treatment of intermittent exotropia.

Method: An exhaustive search of the literature from PubMed, Embase, Web of Science, and Cochrane Library databases was carried out until July 2022. No language restrictions were applied. The literature was rigorously screened against eligibility criteria. Weighted mean differences and 95% confidence interval (CI) were calculated.

Results: A total of 4 articles with 617 participants were included in this meta-analysis. Our pooled results showed that PTO exhibited superior effects compared to observation, with greater decrease in exotropia control at distance and near (MD = -0.38, 95% CI: -0.57 to -0.20, p < 0.001; MD = -0.36, 95% CI: -0.54 to -0.18, p < 0.001); patients subjected to PTO therapy had greater decrease in distance deviations (MD = -1.95, 95% CI: -3.13 to -0.76, p = 0.001), and there was greater improvement in near stereoacuity among the PTO group in comparison with the observation group (p < 0.001).

Conclusions: The present meta-analysis indicated that PTO therapy showed a better effect in improving control and near stereopsis and decreasing distance exodeviation angle of children with intermittent exotropia in comparison with observation.

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部分时间闭塞治疗对间歇性外斜视控制的影响：随机对照试验的荟萃分析。

背景：间歇性外斜视是儿童外斜视最常见的亚型。部分时间闭塞（PTO）作为一种抗抑制疗法应用于间歇性外斜视的非手术治疗。目的：比较PTO治疗间歇性外斜视的疗效。方法：在2022年7月之前，从PubMed、Embase、Web of Science和Cochrane Library数据库中对文献进行了详尽的检索。没有语言限制。根据合格标准对文献进行了严格筛选。计算加权平均差和95%置信区间（CI）。结果：本荟萃分析共纳入4篇文章，617名参与者。我们的汇总结果显示，与观察结果相比，PTO表现出更好的效果，在远处和近处外斜视控制的下降幅度更大（MD=-0.38，95%CI:0.57至-0.20，p＜0.001；MD=-0.36，95%CI:0.54至-0.18，p＜001）；接受PTO治疗的患者的距离偏差降低幅度更大（MD=1.95，95%CI:3.13至-0.76，p=0.001），与观察组相比，PTO组的近立体视锐度有更大的改善（p＜0.001）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.