Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma.

IF 1.6 4区医学 Q4 TOXICOLOGY Toxicological Research Pub Date : 2022-04-01 DOI:10.1007/s43188-022-00125-5

Chaeyeong Kim, Gyeyeong Kong, Hyunji Lee, Quangdon Tran, Thuy-Trang T Vo, So Hee Kwon, Jisoo Park, Seon-Hwan Kim, Jongsun Park

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引用次数: 3

Abstract

Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (SREC-2). SREC-1 plays an important role in the binding and endocytosis of various endogenous and exogenous ligands. Many studies have been carried out on modified low-density lipoprotein internalization activity, but there have been few studies on SCARF2. Higher expression of SCARF2 has been found in glioblastoma (GBM) than normal brain tissue. Through analysis of The Cancer Genome Atlas database, it was confirmed that SCARF2 is widely expressed in GBM, and increased SCARF2 expression correlated with a poor prognosis in patients with glioma. The results of this study showed that the expression of SCARF2 is increased in GBM cell lines and patients, suggesting that SCARF2 may be a potential diagnostic marker and therapeutic molecule for cancers including glioma.

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清除受体F类成员2 (SCARF2)作为胶质母细胞瘤的新治疗靶点。

清道夫受体F类成员2 (SCARF2)由具有非常大细胞质结构域的内皮细胞表达，是第二种同型，也称为内皮细胞2表达的清道夫受体(srec2)。srec1在各种内源性和外源性配体的结合和内吞作用中起重要作用。目前对改性低密度脂蛋白内化活性的研究较多，但对SCARF2的研究较少。与正常脑组织相比，在胶质母细胞瘤(GBM)中发现了更高的SCARF2表达。通过对The Cancer Genome Atlas数据库的分析，证实SCARF2在GBM中广泛表达，且SCARF2表达升高与胶质瘤患者预后不良相关。本研究结果显示，SCARF2在GBM细胞系和患者中表达增加，提示SCARF2可能是胶质瘤等癌症的潜在诊断标志物和治疗分子。

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来源期刊

Toxicological Research TOXICOLOGY-

CiteScore

4.20

自引率

4.30%

发文量

期刊介绍： Toxicological Research is the official journal of the Korean Society of Toxicology. The journal covers all areas of Toxicological Research of chemicals, drugs and environmental agents affecting human and animals, which in turn impact public health. The journal’s mission is to disseminate scientific and technical information on diverse areas of toxicological research. Contributions by toxicologists, molecular biologists, geneticists, biochemists, pharmacologists, clinical researchers and epidemiologists with a global view on public health through toxicological research are welcome. Emphasis will be given to articles providing an understanding of the toxicological mechanisms affecting animal, human and public health. In the case of research articles using natural extracts, detailed information with respect to the origin, extraction method, chemical profiles, and characterization of standard compounds to ensure the reproducible pharmacological activity should be provided.