Elaborate Evaluation of Farnsworth Dichotomous D-15 Panel Test Can Help Differentiate between Best Vitelliform Macular Dystrophy and Autosomal Recessive Bestrophinopathy.

IF 2 4区 医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2023-01-12 DOI:10.1159/000528615
Katarzyna Nowomiejska, Fadi Nasser, Agnieszka Brzozowska, Robert Rejdak, Eberhart Zrenner
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Abstract

Introduction: The colour vision in bestrophinopathies has not been assessed in detail so far. The aim of this study was to explore the extent to which distinct types of bestrophinopathies differ in regard to colour vision deficiencies using Farnsworth Dichotomous D-15 and Lanthony Desaturated D-15 panel tests.

Methods: Both D-15 tests were performed in 52 eyes of 26 patients with Best vitelliform macular dystrophy (BVMD) and 10 eyes of 5 patients with autosomal recessive bestrophinopathy (ARB). Two methods were used for a quantitative assessment of the colour vision deficiencies: moment of inertia method and Bowman method. The following parameters were calculated: confusion angle, confusion index (C-index), selectivity index (S-index), total error score (TES), and colour confusion index (CCI).

Results: The median value of confusion angle for all stages of BVMD fell into a narrow range around 62, indicating normal results. The median confusion angle value was 57 in ARB patients within a very wide range down to -82, indicating non-specific deficits. These differences were statistically significant. Significantly abnormal C-index and CCI values were found only in ARB patients, being 2.0 and 1.49, respectively. The majority of parameters of D-15 tests were independent of the visual acuity in both bestrophinopathies.

Conclusions: Elaborate evaluation of the D-15 panel tests might help establish a differential diagnosis between different bestrophinopathies, as the pattern of the colour vision loss is different between BVMD and ARB. The quantitative parameters of colour vision tests in bestrophinopathies are independent of the visual acuity.

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Farnsworth二分D-15面板试验的精细评估有助于区分最佳葡萄状黄斑营养不良和常染色体隐性营养不良。
引言:到目前为止,还没有对嗜营养菌病的色觉进行详细评估。本研究的目的是使用Farnsworth二分D-15和Lanthony去饱和D-15面板测试,探讨不同类型的嗜营养菌病在色觉缺陷方面的差异程度。方法:对26例Best卵黄状黄斑营养不良(BVMD)患者的52眼和5例常染色体隐性遗传性营养不良(ARB)患者的10眼进行D-15测试。有两种方法用于定量评估色觉缺陷:惯性矩法和鲍曼法。计算了以下参数:混淆角、混淆指数(C指数)、选择性指数(S指数)、总误差评分(TES)和颜色混淆指数(CCI)。ARB患者的中位混淆角值为57,在非常宽的范围内降至-82,表明非特异性缺陷。这些差异具有统计学意义。仅在ARB患者中发现显著异常的C指数和CCI值,分别为2.0和1.49。D-15测试的大多数参数与两种营养不良的视力无关。结论:由于BVMD和ARB之间的色觉丧失模式不同,对D-15小组测试的详细评估可能有助于在不同的营养不良疾病之间建立鉴别诊断。营养不良患者的色觉测试的定量参数与视力无关。
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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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