Effect of Magnesium Status on Microalbuminuria in Type 2 Diabetic Patients.

Q2 Medicine Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2023-01-01 DOI:10.2174/1871525720666220425120457

Maryam Rezaei, Reza Khazaei, Zabihullah Mohaqiq, Vajehallah Raeesi, Tahereh Farkhondeh, Saeed Samarghandian

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引用次数: 1

Abstract

Background: There are several controversies regarding the association between serum magnesium depletion and microalbuminuria in type 2 diabetic patients.

Objective: Therefore, this study aimed to assess serum magnesium concentrations in Type 2 diabetic patients with microalbuminuria and normoalbuminuria in Birjand, Iran, in 2019.

Methods: In this cross-sectional study, 25 type 2 diabetes patients with microalbuminuria were enrolled as the case group and 25 type 2 diabetes patients with normoalbuminuria as the control group. Both groups were matched for age, sex, hypertension, and dyslipidemia. Blood samples were obtained for serum magnesium measurement.

Results: Our findings showed no significant difference between serum magnesium concentration in the case and control groups (mean serum magnesium concentration for case group: 2.34 ± 0.35 mg/dl and control group: 2.27 ± 0.33 mg/dl). Pearson correlation coefficient analysis did not show any correlation between serum magnesium levels and urine albumin levels in patients with microalbuminuria versus patients with normoalbuminuria (r = 0.06, p = 0.67).

Conclusion: This study did not indicate a correlation between serum magnesium concentrations and microalbuminuria in Type 2 diabetic patients.

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镁对2型糖尿病患者微量白蛋白尿的影响。

背景:关于2型糖尿病患者血清镁消耗与微量白蛋白尿之间的关系存在一些争议。因此，本研究旨在评估2019年伊朗Birjand 2型糖尿病伴微量白蛋白尿和正常白蛋白尿患者的血清镁浓度。方法:采用横断面研究方法，选取25例2型糖尿病伴微量蛋白尿患者为病例组，25例2型糖尿病伴正常蛋白尿患者为对照组。两组在年龄、性别、高血压和血脂异常方面都是匹配的。取血样测定血清镁含量。结果:病例组与对照组血清镁浓度差异无统计学意义(病例组平均血清镁浓度为2.34±0.35 mg/dl，对照组为2.27±0.33 mg/dl)。Pearson相关系数分析未显示微量白蛋白尿患者与正常白蛋白尿患者血清镁水平和尿白蛋白水平之间有任何相关性(r = 0.06, p = 0.67)。结论:本研究未发现2型糖尿病患者血清镁浓度与微量白蛋白尿之间存在相关性。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.