Involvement of Impaired Angiogenesis and Myelosuppression in Antiresorptive-agent Related Osteonecrosis of the Jaw Mouse Model.

Q3 Medicine Tokai Journal of Experimental and Clinical Medicine Pub Date : 2023-04-20

Hisao Igarashi, Satoru Nishizawa, Takeshi Miyamoto, Atsuhiko Hikita, Kazuto Hoshi

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引用次数: 0

Abstract

Objective: To explore the involvement of bone marrow cells and angiogenesis in the pathogenesis of antiresorptive agent-related osteonecrosis of the jaw (ARONJ).

Methods: We performed micro-computed tomography (CT) and histological analyses in an ARONJ mouse model generated using bisphosphonate (BP) and cyclophosphamide (CY).

Results: Micro-CT analysis showed that BP and CY inhibited osteoneogenesis in the extraction socket. Histological analysis at 3 days after tooth extraction showed inhibition of vascular endothelial cell and mesenchymal stem cell mobilization into the extraction socket. When neovascularization of the extraction fossa was observed from as early as 1 day after extraction, it occurred predominantly in the area adjacent to the extraction fossa and close to the bone marrow cavity. In addition, the extraction fossa communicated with the adjacent bone marrow via the vasculature. Histological evaluation of the alveolar bone marrow around the extraction socket showed a decrease in bone marrow cells in the BP + CY group.

Conclusion: Both inhibition of angiogenesis and suppression of bone marrow cell mobilization are involved in the pathogenesis of ARONJ.

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抗吸收剂相关性颌骨骨坏死小鼠模型中血管生成受损和骨髓抑制的参与。

目的:探讨骨髓细胞和血管生成在抗吸收剂相关性颌骨骨坏死(ARONJ)发病中的作用。方法:对双膦酸盐(BP)和环磷酰胺(CY)制备的ARONJ小鼠模型进行显微计算机断层扫描(CT)和组织学分析。结果:微ct分析显示BP和CY对拔牙槽骨形成有抑制作用。拔牙后3天的组织学分析显示，血管内皮细胞和间充质干细胞向拔牙槽内的动员受到抑制。拔牙后1天观察到拔牙窝新生血管，主要发生在拔牙窝附近和靠近骨髓腔的区域。此外，提取窝通过脉管系统与邻近的骨髓相通。拔牙槽周围牙槽骨髓组织学检查显示BP + CY组骨髓细胞减少。结论:血管生成抑制和骨髓细胞动员抑制共同参与了ARONJ的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tokai Journal of Experimental and Clinical Medicine Medicine-Medicine (all)

CiteScore

1.10

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0.00%

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期刊介绍： The Tokai Journal of Experimental and Clinical Medicine, also referred to as Tokai Journal, is an official quarterly publication of the Tokai Medical Association. Tokai Journal publishes original articles that deal with issues of clinical, experimental, socioeconomic, cultural and/or historical importance to medical science and related fields. Manuscripts may be submitted as full-length Original Articles or Brief Communications. Tokai Journal also publishes reviews and symposium proceedings. Articles accepted for publication in Tokai Journal cannot be reproduced elsewhere without written permission from the Tokai Medical Association. In addition, Tokai Journal will not be held responsible for the opinions of the authors expressed in the published articles.