Observations on hydronephrosis after pig kidney transplantation in baboons.

IF 3.3 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Xenotransplantation Pub Date : 2022-11-01 Epub Date: 2022-09-25 DOI:10.1111/xen.12779

Jeremy B Foote, Mohamed H Bikhet, Christophe Hansen-Estruch, Mariyam Javed, David Ayares, Hidetaka Hara, Abhinav Humar, Devin E Eckhoff, David K C Cooper

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Abstract

We have seen hydronephrosis (obstructive nephropathy) at necropsy in 3 of 11 (21%) genetically-engineered pig kidneys that functioned in baboons for >36 days, even when the clinical and histopathological features of rejection were minimal. We briefly report one such case and illustrate the macroscopic and microscopic appearances of such a kidney and ureter. The causes of the observed changes remain uncertain. In our small experience, there seems to be no correlation between the development of hydronephrosis and (i) the surgical technique, (ii) the genotype of the pig, (iii) the length of the pig ureter, or (iv) the immunosuppressive and anti-inflammatory therapy administered. We suggest that the distal ureteric thickening may be the result of an inflammatory response. In two cases, we resolved the problem by carrying out a secondary side-to-side anastomosis between the proximal pig ureter and the baboon bladder.

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狒狒猪肾移植后肾积水的观察。

我们在尸检中发现，11个基因工程猪肾脏中有3个（21%）在狒狒身上功能超过36天，即使排斥反应的临床和组织病理学特征很小。我们简要报告了一个这样的病例，并说明了这样的肾脏和输尿管的宏观和微观表现。观察到的变化的原因仍然不确定。根据我们的小经验，肾积水的发展与（i）手术技术、（ii）猪的基因型、（iii）猪输尿管的长度或（iv）免疫抑制和抗炎治疗之间似乎没有相关性。我们认为远端输尿管增厚可能是炎症反应的结果。在两个案例中，我们通过在猪输尿管近端和狒狒膀胱之间进行二次侧对侧吻合来解决这个问题。

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来源期刊

Xenotransplantation 医学-医学：研究与实验

CiteScore

6.80

自引率

15.40%

发文量

审稿时长

>12 weeks

期刊介绍： Xenotransplantation provides its readership with rapid communication of new findings in the field of organ and tissue transplantation across species barriers.The journal is not only of interest to those whose primary area is xenotransplantation, but also to veterinarians, microbiologists and geneticists. It also investigates and reports on the controversial theological, ethical, legal and psychological implications of xenotransplantation.