Long term functional outcomes of a permanent antibiotic cement spacer for chronic distal tibial osteomyelitis in a patient with diabetes

Elizabeth G. Zolper , Idanis M. Perez-Alvarez , Paige K. Dekker , Paul S. Cooper , Kenneth L. Fan , Karen K. Evans
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Abstract

A 66-year-old male with chronic right distal tibial osteomyelitis presents with erythema and a draining sinus tract concerning for acute exacerbation. Previously stable on amoxicillin/clavulanate, worsening symptoms for 3–4 months prompted referral. Following evaluation, treatment consisted of debridement, insertion of an antibiotic cement spacer into the partial cortical tibial defect and free flap coverage. At five-year follow up, the antibiotic spacer remains in place without recurrence of osteomyelitis and with preserved function. Further investigation is needed to validate permanent retention of an antibiotic spacer as an alternative to vascularized or non-vascularized bone grafts for management of chronic tibial osteomyelitis in the comorbid diabetic limb salvage population.

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永久性抗生素水泥间隔器治疗糖尿病患者慢性胫骨远端骨髓炎的长期功能结果
66岁男性慢性右胫骨远端骨髓炎表现为红斑和引流窦道有关急性加重。先前阿莫西林/克拉维酸稳定,症状恶化3-4个月提示转诊。评估后,治疗包括清创,在部分胫骨皮质缺损内插入抗生素水泥间隔器和自由皮瓣覆盖。在5年的随访中,抗生素间隔剂仍然存在,没有骨髓炎复发,并保留了功能。需要进一步的研究来验证永久保留抗生素间隔物作为血管化或非血管化骨移植物的替代方法,以治疗合并糖尿病残肢人群的慢性胫骨骨髓炎。
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