A spotlight on application of microwave-assisted modifications of plant derived polymers in designing novel drug delivery systems.

IF 1.8 4区 化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2023-01-01 DOI:10.1080/15685551.2023.2194176
Girish Meravanige Basavarajappa, K M Priyanka, Prakash Goudanavar, Lakshmi G Narasimha, N Raghavendra Naveen, Buduru Gowthami, Santosh Fattepur, Predeepkumar Narayanappa Shiroorkar, Sreeharsha Nagaraja, Mallikarjun Telsang, Veeriah Chowdary Jasthi, Pavan Kumar Pavagada Sreenivasalu
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Abstract

Polymers are a fundamental part of numerous industries and can be conjugated with many other materials and components to have a vast array of products. Biomaterials have been extensively studied for their application in pharmaceutical formulation development, tissue engineering, and biomedical areas. However, the native form of many polymers has limitations concerning microbial contamination, susceptibility, solubility, and stability. Chemical or physical modifications can overcome these limitations by tailoring the properties of polymers to meet several requirements. The polymer modifications are interdisciplinary, cutting across conventional materials, physics, biology, chemistry, medicine, and engineering limitations. Microwave irradiation has become a well-established technique for a few decades to drive and promote chemical modification reactions. This technique allows ease of temperature and power control to perform the synthesis protocols efficiently. Additionally, microwave irradiation contributes to green and sustainable chemistry. In this contribution, microwave-assisted polymer modifications were described with a special focus on their application in developing several novel dosage forms.

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重点介绍了微波辅助修饰植物衍生聚合物在设计新型给药系统中的应用。
聚合物是许多工业的基本组成部分,可以与许多其他材料和成分结合,产生大量的产品。生物材料因其在药物配方开发、组织工程和生物医学领域的应用而得到了广泛的研究。然而,许多聚合物的天然形式在微生物污染、易感性、溶解度和稳定性方面存在局限性。化学或物理改性可以通过调整聚合物的性质来满足几种要求,从而克服这些限制。聚合物修饰是跨学科的,跨越了传统材料、物理、生物、化学、医学和工程的限制。几十年来,微波辐射已经成为一种成熟的技术来驱动和促进化学修饰反应。该技术允许易于温度和功率控制,以有效地执行合成协议。此外,微波辐射有助于绿色和可持续的化学。在这篇贡献中,微波辅助聚合物修饰被描述,特别关注它们在开发几种新剂型中的应用。
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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
期刊最新文献
Synthesis and properties of bio-based semi-aromatic heat-resistant copolymer polyamide 5T-co-6T. Progress in synthesis, modification, characterization and applications of hyperbranched polyphosphate polyesters. The effect of polycarboxylate superplasticizer on the strength and hydration performance of alkali slag building materials. Ionic Organic Network-based C3-symmetric@Triazine core as a selective Hg+2 sensor. Cyclodextrin-grafted redox-responsive hydrogel mediated by disulfide bridges for regulated drug delivery.
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