Risk of cardiovascular disease is driven by different combinations of environmental, medical and behavioral factors: Building a conceptual model for cumulative risk assessment.

IF 3 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Human and Ecological Risk Assessment Pub Date : 2021-05-26 DOI:10.1080/10807039.2021.1925083
Roxolana Kashuba, Charles Menzie, Lawrence Martin
{"title":"Risk of cardiovascular disease is driven by different combinations of environmental, medical and behavioral factors: Building a conceptual model for cumulative risk assessment.","authors":"Roxolana Kashuba,&nbsp;Charles Menzie,&nbsp;Lawrence Martin","doi":"10.1080/10807039.2021.1925083","DOIUrl":null,"url":null,"abstract":"<p><p>The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health (NIEHS) held a workshop in 2012 to discuss principles and applications of cumulative risk assessment (CRA). The workshop organizers chose cardiovascular disease (CVD) as an example health outcome for which cumulative risk considerations could illuminate environmental and health management strategies. To guide discussions, we developed a series of conceptual models illustrating factors influencing CVD. The CVD conceptual model represents complex processes across varying space and time scales, different causal pathways, and multiple chemical and non-chemical stressors and factors. It includes causal influences of environmental exposures and lifestyle choices, in the context of genetics and medical factors. The representation of cumulative risk as a network of interrelated nodes and arrows helps define and organize the problem and available information, determine the scope and scale, and creates a platform for analysis. It provides an interface for discussing how different entities (e.g., environmental versus health-driven organizations) can work together on different parts of the problem, and facilitates relative risk ranking and management triage. Color coding is used to distinguish categories of stressors and possible oversight responsibility. This work informs guidelines for CRA planning and assessment of factor combinations affecting real-world risk.</p>","PeriodicalId":13118,"journal":{"name":"Human and Ecological Risk Assessment","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10807039.2021.1925083","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human and Ecological Risk Assessment","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/10807039.2021.1925083","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 1

Abstract

The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health (NIEHS) held a workshop in 2012 to discuss principles and applications of cumulative risk assessment (CRA). The workshop organizers chose cardiovascular disease (CVD) as an example health outcome for which cumulative risk considerations could illuminate environmental and health management strategies. To guide discussions, we developed a series of conceptual models illustrating factors influencing CVD. The CVD conceptual model represents complex processes across varying space and time scales, different causal pathways, and multiple chemical and non-chemical stressors and factors. It includes causal influences of environmental exposures and lifestyle choices, in the context of genetics and medical factors. The representation of cumulative risk as a network of interrelated nodes and arrows helps define and organize the problem and available information, determine the scope and scale, and creates a platform for analysis. It provides an interface for discussing how different entities (e.g., environmental versus health-driven organizations) can work together on different parts of the problem, and facilitates relative risk ranking and management triage. Color coding is used to distinguish categories of stressors and possible oversight responsibility. This work informs guidelines for CRA planning and assessment of factor combinations affecting real-world risk.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
心血管疾病的风险是由环境、医疗和行为因素的不同组合驱动的:建立累积风险评估的概念模型。
美国环境保护署(EPA)和国家环境卫生研究所(NIEHS)于2012年举办了一次讲习班,讨论累积风险评估(CRA)的原则和应用。讲习班组织者选择心血管疾病作为一个健康结果的例子,对其累积风险的考虑可以阐明环境和健康管理战略。为了指导讨论,我们开发了一系列概念模型来说明影响CVD的因素。CVD概念模型代表了跨越不同空间和时间尺度、不同因果途径以及多种化学和非化学应激源和因素的复杂过程。它包括环境暴露和生活方式选择的因果影响,在遗传和医学因素的背景下。将累积风险表示为由相互关联的节点和箭头组成的网络,有助于定义和组织问题和可用信息,确定范围和规模,并创建分析平台。它提供了一个界面,用于讨论不同实体(例如,环境与健康驱动的组织)如何就问题的不同部分进行合作,并促进了相对风险排序和管理分类。颜色编码用于区分压力源的类别和可能的监督责任。这项工作为CRA规划和评估影响现实世界风险的因素组合提供指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Human and Ecological Risk Assessment
Human and Ecological Risk Assessment 环境科学-环境科学
CiteScore
9.60
自引率
2.30%
发文量
68
审稿时长
2 months
期刊介绍: Human and Ecological Risk Assessment provides a resource for professionals researching and assessing environmental hazards to both humans and ecological systems. The editors expect papers published to be original, of sound science, purposeful for risk analysis (assessment, communication, management) and related areas, well written (in English), and a contribution to the scientific literature. The journal''s emphasis is on publication of papers that contribute to improvements in human and ecological health. The journal is an international, fully peer-reviewed publication that publishes eight issues annually. The journal''s scope includes scientific and technical information and critical analysis in the following areas: -Quantitative Risk Assessment- Comparative Risk Assessment- Integrated Human & Ecological Risk Assessment- Risk Assessment Applications to Human & Ecosystems Health- Exposure Assessment- Environmental Fate Assessment- Multi-Media Assessment- Hazard Assessment- Environmental Epidemiology- Statistical Models and Methods- Methods Development/Improvement- Toxicokinetics Modeling- Animal to Human Extrapolation- Risk Perception/Communication- Risk Management- Regulatory Issues
期刊最新文献
Estimating release of the antibiotic metronidazole into the environment from hospital effluents and assessment of the associated ecological risk: a case study in Isfahan, Iran (2023) Associations between perfluoroalkyl substance exposure and lean body mass in US adults: evidence from the NHANES 2015–2018 Exploring the pattern and influencing factors of ecosystem services under multiscale perspective: implications for ecosystem services management Implication of heavy metal(loid)s contamination for human health and preliminary application of water treatment in floodplain area along Mekong River, Lao PDR Soil quality guidelines for dioxins and furans in Canada: A review and international comparison
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1