Risk of cardiovascular disease is driven by different combinations of environmental, medical and behavioral factors: Building a conceptual model for cumulative risk assessment.
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引用次数: 1
Abstract
The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health (NIEHS) held a workshop in 2012 to discuss principles and applications of cumulative risk assessment (CRA). The workshop organizers chose cardiovascular disease (CVD) as an example health outcome for which cumulative risk considerations could illuminate environmental and health management strategies. To guide discussions, we developed a series of conceptual models illustrating factors influencing CVD. The CVD conceptual model represents complex processes across varying space and time scales, different causal pathways, and multiple chemical and non-chemical stressors and factors. It includes causal influences of environmental exposures and lifestyle choices, in the context of genetics and medical factors. The representation of cumulative risk as a network of interrelated nodes and arrows helps define and organize the problem and available information, determine the scope and scale, and creates a platform for analysis. It provides an interface for discussing how different entities (e.g., environmental versus health-driven organizations) can work together on different parts of the problem, and facilitates relative risk ranking and management triage. Color coding is used to distinguish categories of stressors and possible oversight responsibility. This work informs guidelines for CRA planning and assessment of factor combinations affecting real-world risk.
期刊介绍:
Human and Ecological Risk Assessment provides a resource for professionals researching and assessing environmental hazards to both humans and ecological systems. The editors expect papers published to be original, of sound science, purposeful for risk analysis (assessment, communication, management) and related areas, well written (in English), and a contribution to the scientific literature.
The journal''s emphasis is on publication of papers that contribute to improvements in human and ecological health. The journal is an international, fully peer-reviewed publication that publishes eight issues annually. The journal''s scope includes scientific and technical information and critical analysis in the following areas:
-Quantitative Risk Assessment-
Comparative Risk Assessment-
Integrated Human & Ecological Risk Assessment-
Risk Assessment Applications to Human & Ecosystems Health-
Exposure Assessment-
Environmental Fate Assessment-
Multi-Media Assessment-
Hazard Assessment-
Environmental Epidemiology-
Statistical Models and Methods-
Methods Development/Improvement-
Toxicokinetics Modeling-
Animal to Human Extrapolation-
Risk Perception/Communication-
Risk Management-
Regulatory Issues