Occurrence and Severity of Suicidal Ideation in Adults With Neurofibromatosis Participating in a Mind-Body RCT.

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES Cognitive and Behavioral Neurology Pub Date : 2023-03-01 DOI:10.1097/WNN.0000000000000332
Ethan G Lester, Katherine E Wang, Jaishri O Blakeley, Ana-Maria Vranceanu
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Abstract

Background: Emotional distress can lead to suicidal ideation and potentially suicide completion, yet there is very little literature on suicidal ideation in individuals with a diagnosis of neurofibromatosis (NF; NF1, NF2, and schwannomatosis).

Objective: To examine the baseline occurrence, severity, and clinical correlates of suicidal ideation in adults with NF.

Method: Individuals with NF (N = 220) completed assessments measuring depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), perceived stress (Perceived Stress Scale-10), pain (Graded Chronic Pain Scale and PROMIS Pain Interference Short Form 8a), and general quality of life (World Health Organization Quality of Life-Brief version) before beginning a two-arm, single-blind randomized control trial of a live-video mind-body program for stress management and resiliency.

Results: Nineteen percent (n = 42) of the individuals experienced suicidal ideation (ie, >0; ideation present several days or greater). More individuals with NF2 experienced suicidal ideation compared with those with NF1 or schwannomatosis. All of the clinical variables except pain intensity were significantly correlated ( P < 0.01) with greater suicidal ideation. Suicidal ideation in individuals with NF was comparable to or higher than that in other medical populations (eg, cancer, dermatological, neurologic). Depression and poor psychological quality of life significantly increased the risk for suicidal ideation.

Conclusion: Suicidal ideation was relatively prevalent in individuals with NF seeking participation in a mind-body randomized controlled trial. NF clinicians should be prepared to discuss these concerns and provide resources when suicidal ideation is present.

Clinical trial registration: ClinicalTrials.gov (Identifier NCT03406208).

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参加身心随机对照试验的神经纤维瘤病成年人自杀意念的发生率和严重程度。
背景:情绪困扰会导致自杀意念和潜在的自杀完成,但关于神经纤维瘤病(NF;NF1、NF2和神经鞘瘤病)患者自杀意念的文献很少,以及患有NF的成年人自杀意念的临床相关性。方法:患有NF的个体(N=220)完成了测量抑郁(患者健康问卷-9)、焦虑(广泛性焦虑障碍-7)、感知压力(感知压力量表-10)、疼痛(分级慢性疼痛量表和PROMIS疼痛干扰简表8a),和一般生活质量(世界卫生组织生活质量简报版),然后开始一项用于压力管理和恢复的实时视频身心计划的双臂、单盲随机对照试验。结果:19%(n=42)的个体有自杀意念(即>0;意念出现数天或更长时间)。与NF1或神经鞘瘤病患者相比,更多的NF2患者出现自杀意念。除疼痛强度外,所有临床变量均与较大的自杀意念显著相关(P<0.01)。NF患者的自杀念头与其他医学人群(如癌症、皮肤科、神经科)相当或更高。抑郁症和不良的心理生活质量显著增加了产生自杀意念的风险。结论:在寻求参与身心随机对照试验的NF患者中,自杀意念相对普遍。NF临床医生应准备好讨论这些问题,并在出现自杀意念时提供资源。临床试验注册:ClinicalTrials.gov(标识符NCT03406208)。
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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
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