WITHDRAWN: Screening and in vitro Biological Evaluation of Novel Multiple Tyrosine Kinases Inhibitors as Promising Anticancer Agents

IF 2.6 4区 医学 Q3 CHEMISTRY, MEDICINAL Anti-cancer agents in medicinal chemistry Pub Date : 2025-01-01 DOI:10.2174/1871520623666230403104816
Xiuying Li, Pinglang Ruan, Gang Jiang, Weidong Zhang
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Abstract

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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新型多种酪氨酸激酶抑制剂的筛选及体外生物学评价。
背景:酪氨酸激酶已成为几种癌症相关通路的关键刺激驱动因子。这在具有调节细胞生长和凋亡等功能的非小细胞肺癌中尤为明显。酪氨酸激酶抑制剂(TKI)是一种可以改善癌症患者生活质量的突破性选择。本研究旨在寻找更有效的酪氨酸激酶抑制剂。方法:本研究通过基于结构的虚拟筛选和实验验证,筛选TargetMol中可能成为肺癌潜在TKI的天然产物。此外,还探讨了被击中的化合物与酪氨酸激酶的结合。结果:从研究结果来看,Gramicidin和Tannic acid与四种酪氨酸激酶(ALK、TRK、MET和ABL)有很强的相互作用,并以浓度依赖性的方式显著抑制A549细胞的活力。结论:革兰西丁和单宁酸可能是潜在的多发性TKI,是有前景的抗癌药物,值得进一步研究。
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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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