Potential Antiaging and Hepatoprotective Effects of Acanthopanax senticosus Extracts in Adult Rat Models.

IF 2.2 4区医学 Q3 GERIATRICS & GERONTOLOGY Rejuvenation research Pub Date : 2023-04-01 DOI:10.1089/rej.2022.0051

Chaeyeong Kim, Hye-Min Bae, Inkyung Baik

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引用次数: 1

Abstract

Data regarding plant extracts with antiaging properties, particularly through the biological process involving telomeres and telomerase, are limited. Thus, this study aimed to investigate the effects of Acanthopanax senticosus extract (ASE) supplementation on leukocyte telomere length (LTL), telomerase, and inflammatory and metabolic markers in adult animal models. A freeze-dried product of ethanol extracts was prepared using a mixture product of stem and root ASE. In a 24-week experiment that included 24-week-old Sprague Dawley male rats, experimental rats (n = 10) were administrated with 7 mg/day of ASE dissolved in saline and control rats (n = 10) with saline. All rats had access to chow and tap water ad libitum. Their LTL and plasma levels of telomerase and inflammatory and metabolic markers were assayed and compared between the two groups. The experimental rats showed significantly longer LTL (p < 0.05) and lower plasma levels of alanine aminotransferase (p < 0.05) and aspartate aminotransferase (p = 0.08) compared with the control. In addition, LTL was correlated with the aforementioned biochemical parameters of liver function test among experimental rats only. No significant differences in plasma levels of telomerase and inflammatory and metabolic markers were observed. These findings indicate that ASE supplementation may attenuate LTL shortening and reduce liver biochemical parameters, indicating its potential antiaging and hepatoprotective effects without any adverse metabolic response.

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刺五加提取物对成年大鼠模型的潜在抗衰老和肝保护作用。

关于具有抗衰老特性的植物提取物的数据，特别是通过涉及端粒和端粒酶的生物过程，是有限的。因此，本研究旨在研究补充刺五加提取物(ASE)对成年动物模型白细胞端粒长度(LTL)、端粒酶以及炎症和代谢标志物的影响。以茎、根ASE混合产物为原料制备乙醇提取物冻干产物。在24周的实验中，选取24周龄的Sprague Dawley雄性大鼠，实验大鼠(n = 10)给予7 mg/d溶解于生理盐水中的ASE，对照组大鼠(n = 10)给予生理盐水。所有老鼠都可以随意获得食物和自来水。对两组患者进行LTL、血浆端粒酶水平、炎症和代谢标志物的测定和比较。与对照组相比，实验组大鼠LTL明显延长(p p p = 0.08)。此外，LTL仅在实验大鼠中与上述肝功能生化指标相关。血浆端粒酶、炎症和代谢标志物水平无显著差异。这些结果表明，补充ASE可能会减缓LTL缩短，降低肝脏生化参数，表明其潜在的抗衰老和肝脏保护作用，而没有任何不良代谢反应。

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来源期刊

Rejuvenation research 医学-老年医学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Rejuvenation Research publishes cutting-edge, peer-reviewed research on rejuvenation therapies in the laboratory and the clinic. The Journal focuses on key explorations and advances that may ultimately contribute to slowing or reversing the aging process, and covers topics such as cardiovascular aging, DNA damage and repair, cloning, and cell immortalization and senescence. Rejuvenation Research coverage includes: Cell immortalization and senescence Pluripotent stem cells DNA damage/repair Gene targeting, gene therapy, and genomics Growth factors and nutrient supply/sensing Immunosenescence Comparative biology of aging Tissue engineering Late-life pathologies (cardiovascular, neurodegenerative and others) Public policy and social context.