A review of experimental techniques for erectile function researches and development of medical technology using animal erectile dysfunction models in sexual and reproductive medicine.

IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Reproductive Medicine and Biology Pub Date : 2023-04-03 eCollection Date: 2023-01-01 DOI:10.1002/rmb2.12513
Tomoya Kataoka, Yuji Hotta, Kazunori Kimura
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Abstract

Background: Erectile dysfunction (ED) is one of the causes of male infertility and is a disease that requires treatment. The first-line drugs for ED are phosphodiesterase 5 (PDE-5) inhibitors, and further treatment options are currently limited. Medical technologies, such as genetic control and regenerative medicine, are developing rapidly. Research on erectile function is progressing rapidly, coupled with technological innovations in other areas.

Methods: A PubMed search using the keywords "animal (rat, mouse, rabbit, dog, and monkey)" and "erectile" was conducted, and all relevant peer-reviewed English results were evaluated.

Main findings: The methods for evaluating erectile function include intracavernous pressure (ICP) measurements, isometric tension studies, and dynamic infusion cavernosometry. Papers also reported various disease model animals for the study of diabetes mellitus, cavernous nerve injury, and drug-induced ED.

Conclusion: Basic research on ED treatment has progressed rapidly over the past 20 years. In particular, research on the mechanism of ED has been accelerated by the publication of a study on the evaluation of erectile function using ICP measurements in rats. In addition, molecular biological experimental methods such as polymerase chain reaction (PCR) and western blotting have become relatively easy to perform due to technological progress, thus advancing research development.

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回顾性医学和生殖医学中使用动物勃起功能障碍模型进行勃起功能研究和医疗技术开发的实验技术。
背景:勃起功能障碍(ED)是导致男性不育的原因之一,也是一种需要治疗的疾病。治疗勃起功能障碍的一线药物是磷酸二酯酶 5 (PDE-5) 抑制剂,目前进一步的治疗方案有限。基因控制和再生医学等医疗技术发展迅速。随着其他领域的技术革新,有关勃起功能的研究也在迅速发展:方法:使用关键词 "动物(大鼠、小鼠、兔子、狗和猴子)"和 "勃起 "进行 PubMed 搜索,并对所有相关的同行评审英文结果进行评估:评估勃起功能的方法包括海绵体内压(ICP)测量、等距张力研究和动态灌注海绵体测压法。论文还报告了研究糖尿病、海绵体神经损伤和药物诱发 ED 的各种疾病模型动物:结论:在过去的 20 年中,有关 ED 治疗的基础研究进展迅速。尤其是利用 ICP 测量大鼠勃起功能评估研究的发表,加速了对 ED 机制的研究。此外,由于技术进步,聚合酶链式反应(PCR)和 Western 印迹等分子生物学实验方法变得相对容易,从而推动了研究的发展。
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来源期刊
CiteScore
5.70
自引率
5.90%
发文量
53
审稿时长
20 weeks
期刊介绍: Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.
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