Improving the Identification of Frailty in Long-Term Care Residents: A Cross-Sectional Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-10-01 DOI:10.1177/10998004221100797

Haritz Arrieta, Chloe Rezola-Pardo, Begoña Sanz, Janire Virgala, Mertxe Lacunza-Zumeta, Ana Rodriguez-Larrad, Jon Irazusta

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引用次数: 1

Abstract

Purpose: To compare the capacity of blood myostatin concentration and physical, cognitive, and affective function tests to predict frailty among long-term care (LTC) residents.

Methods: This cross-sectional analysis used baseline data from three randomized controlled trials involving 260 older adults in 14 LTC centers. Serum myostatin levels were analyzed by enzyme-linked immunosorbent assay. Frailty, physical fitness, cognitive and affective functions were assessed using validated tests and scales.

Results: The Timed Up and Go, gait speed, 6-minute walk, and Berg Balance Scale had excellent capabilities in identifying frail individuals in accordance with Fried's Frailty Phenotype (FFP). The best tests for identifying frailty in accordance with the Clinical Frailty Scale (CFS) were Timed Up and Go and Berg Balance Scale. For the Tilburg Frailty Indicator (TFI), the best tests were Quality of Life in Alzheimer's Disease (QoL-AD) and Goldberg Anxiety. Myostatin, along with physical, cognitive, and affective function tests, improved the capability of the hand grip, arm-curl, Montreal Cognitive Assessment, Goldberg Anxiety, Goldberg Depression, and QoL-AD to identify frailty according to FFP, while myostatin improved CFS-defined frailty identification by the hand grip, arm-curl, 6-minute walk test, Berg Balance Scale, 30-second chair-stand, gait speed, Montreal Cognitive Assessment, Goldberg Anxiety, and De Jong-Gierveld Loneliness Scale.

Conclusion: Among LTC residents, serum myostatin was associated with being frail according to FFP and CFS. However, this measure was less discriminating of frailty than physical fitness tests (for FFP and CFS) and affective function parameters (for TFI). However, evaluated concurrently with physical, cognitive, and affective parameters, myostatin improved the capabilities of these measures to predict CFS-defined frailty.

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改善长期照护居民虚弱辨识:一项横断面研究。

目的:比较长期护理(LTC)患者血液肌肉生长抑制素浓度和身体、认知和情感功能测试预测虚弱的能力。方法:本横断面分析使用了来自14个LTC中心的260名老年人的三个随机对照试验的基线数据。采用酶联免疫吸附法分析血清肌生长抑制素水平。虚弱、体能、认知和情感功能使用有效的测试和量表进行评估。结果:Timed Up and Go、步态速度、6分钟步行和Berg平衡量表在根据Fried虚弱表型(FFP)识别虚弱个体方面具有出色的能力。根据临床虚弱量表(CFS)识别虚弱的最佳测试是Timed Up and Go和Berg Balance Scale。对于蒂尔伯格衰弱指标(TFI)，最好的测试是阿尔茨海默病生活质量(QoL-AD)和戈德堡焦虑。肌生长抑制素与身体、认知和情感功能测试一起，提高了握力、旋臂、蒙特利尔认知评估、戈德堡焦虑、戈德堡抑郁和ql - ad根据FFP识别虚弱的能力，而肌生长抑制素通过握力、旋臂、6分钟步行测试、伯格平衡量表、30秒站立椅、步态速度、蒙特利尔认知评估、戈德堡焦虑和De Jong-Gierveld孤独量表改善了cfs定义的虚弱识别。结论:根据FFP和CFS，在LTC居民中，血清肌生长抑制素与虚弱相关。然而，与体能测试(针对FFP和CFS)和情感功能参数(针对TFI)相比，这种测量方法对虚弱的辨别能力较弱。然而，与身体、认知和情感参数同时评估时，肌肉生长抑制素提高了这些指标预测cfs定义的虚弱的能力。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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