Novel Migraine Treatments: A Review

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.11607/ofph.3163

Naveen George, Stewart J Tepper

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Abstract

Aims: To present a review of the mechanisms of action, available clinical data, and safety profiles of novel migraine therapeutics to inform practice. Methods: PubMed, Medline, and Google Scholar were searched for randomized controlled trials (24 publications), review articles (15 publications), and other pertinent literature (16 publications) discussing the novel migraine therapeutics available between the years 2010 and 2021. All publications were reviewed to assess the mechanism of action, relevant clinical data, and side effect profile for each novel treatment. Therapeutic gain was also recorded in studies that included a placebo arm. Results: A total of 55 studies were included in the final analysis. In the preventive treatment of migraine, novel medications target calcitonin gene-related peptide (CGRP) and fall into either the monoclonal anti-CGRP or gepant class. For the acute treatment of migraine, novel medications fall into either the ditan or gepant class. Several medical devices have been developed for the acute and preventive treatment of migraine. Conclusion: Novel therapeutics are available for both the prevention and acute treatment of migraine headaches. These new medications and neuromodulatory devices appear overall to be safe and effective in the management of migraine headaches.

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新的偏头痛治疗方法综述

目的:回顾偏头痛新疗法的作用机制、现有临床数据和安全性，为临床实践提供参考。方法:检索PubMed、Medline和谷歌Scholar，检索2010年至2021年间讨论新型偏头痛治疗方法的随机对照试验(24篇出版物)、综述文章(15篇出版物)和其他相关文献(16篇出版物)。对所有出版物进行审查，以评估每种新疗法的作用机制、相关临床数据和副作用概况。在包括安慰剂组的研究中也记录了治疗效果。结果:最终分析共纳入55项研究。在偏头痛的预防治疗中，新型药物以降钙素基因相关肽(CGRP)为靶点，分为抗CGRP单克隆类和抗CGRP类。对于偏头痛的急性治疗，新型药物分为地坦类和妊娠类。已经开发了几种用于偏头痛的急性和预防性治疗的医疗设备。结论:新的治疗方法可用于偏头痛的预防和急性治疗。总的来说，这些新的药物和神经调节装置在治疗偏头痛方面是安全有效的。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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