Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED Journal of microencapsulation Pub Date : 2023-05-01 DOI:10.1080/02652048.2023.2183276

Ran Tao, Qianyu Zhang, Jialing Duan, Ran Chen, Liyun Yao, Ruiteng Zhang, Gang Dong, Huali Chen

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Abstract

Aims: The aim of this study is to develop a liposome that could exert unparalleled antioxidant effects. In the present study, a vitamin C (VC)/vitamin E (VE)-co-loaded multivesicular liposome (VCVE-MVL) was constructed.

Methods: Vitamins were encapsulated in soybean phosphatidylcholine (SPC) and cholesterol (CHO) by multi-emulsification method. The concentration of VC was determined by Fast Blue method. The concentration of VE was determined by high performance liquid chromatography (HPLC). Vitamin antioxidant capacity in vitro and in vivo was determined using β-carotene bleaching.

Results: VCVE-MVL with particle diameter of 848.55 ± 0.29 nm and SPAN of 0.16 ± 0.11 were obtained. The encapsulation efficiency of VC reached 48.51% (w/w)±0.15. Compared with VC/VE solution, VCVE-MVL had a higher permeation efficiency. In addition, the in vitro and ex-vivo antioxidant tests verified the adequate antioxidant activity of VCVE-MVL.

Conclusions: In conclusion, the antioxidant synergistic system we constructed and demonstrated its potential applications in the cosmetics industry.

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含维生素C和维生素E的抗氧化协同体系的构建与评价。

目的:本研究的目的是开发一种能够发挥无与伦比的抗氧化作用的脂质体。本研究构建了维生素C (VC)/维生素E (VE)共载多泡脂质体(VCVE-MVL)。方法:采用多重乳化法制备大豆磷脂酰胆碱(SPC)和胆固醇(CHO)。快速蓝法测定VC的浓度。采用高效液相色谱法测定VE的浓度。采用β-胡萝卜素漂白法测定了维生素的体外和体内抗氧化能力。结果:获得的VCVE-MVL粒径为848.55±0.29 nm, SPAN为0.16±0.11;VC的包封效率达到48.51% (w/w)±0.15。与VC/VE溶液相比，VCVE-MVL具有更高的渗透效率。此外，体外和离体抗氧化试验证实了VCVE-MVL具有足够的抗氧化活性。结论:所构建的抗氧化协同体系在化妆品行业具有一定的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.