Research Progress on TRPA1 in Diseases.

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-04-11 DOI:10.1007/s00232-023-00277-x

Jiajing Li, Hongfei Zhang, Qian Du, Junyu Gu, Jiangbo Wu, Qi Liu, Zhuo Li, Ting Zhang, Jingyu Xu, Rui Xie

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Abstract

For a long time, the physiological activity of TRP ion channels and the response to various stimuli have been the focus of attention, and the physiological functions mediated by ion channels have subtle links with the occurrence of various diseases. Our group has been engaged in the study of ion channels. In recent years, the report rate of TRPA1, the only member of the TRPA subfamily in the newly described TRP channel, has been very high. TRPA1 channels are not only abundantly expressed in peptidergic nociceptors but are also found in many nonneuronal cell types and tissues, and through the regulation of Ca²⁺ influx, various neuropeptides and signaling pathways are involved in the regulation of nerves, respiration, circulation, and various diseases and inflammation throughout the body. In this review, we mainly summarize the effects of TRPA1 on various systems in the body, which not only allows us to have a more systematic and comprehensive understanding of TRPA1 but also facilitates more in-depth research on it in the future.

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TRPA1在疾病中的研究进展

长期以来，TRP离子通道的生理活性和对各种刺激的反应一直是人们关注的焦点，离子通道介导的生理功能与各种疾病的发生有着微妙的联系。我们组一直从事离子通道的研究。近年来，新描述的TRP通道中唯一的TRPA亚家族成员TRPA1的报道率非常高。TRPA1通道不仅在多肽性伤害感受器中大量表达，而且在许多非神经元细胞类型和组织中也有发现，通过调节Ca2+内流，各种神经肽和信号通路参与全身神经、呼吸、循环和各种疾病和炎症的调节。在这篇综述中，我们主要总结了TRPA1对机体各系统的作用，这不仅可以让我们对TRPA1有一个更系统和全面的了解，也有助于我们在未来对其进行更深入的研究。

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来源期刊

Journal of Membrane Biology 生物-生化与分子生物学

CiteScore

4.80

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Membrane Biology is dedicated to publishing high-quality science related to membrane biology, biochemistry and biophysics. In particular, we welcome work that uses modern experimental or computational methods including but not limited to those with microscopy, diffraction, NMR, computer simulations, or biochemistry aimed at membrane associated or membrane embedded proteins or model membrane systems. These methods might be applied to study topics like membrane protein structure and function, membrane mediated or controlled signaling mechanisms, cell-cell communication via gap junctions, the behavior of proteins and lipids based on monolayer or bilayer systems, or genetic and regulatory mechanisms controlling membrane function. Research articles, short communications and reviews are all welcome. We also encourage authors to consider publishing ''negative'' results where experiments or simulations were well performed, but resulted in unusual or unexpected outcomes without obvious explanations. While we welcome connections to clinical studies, submissions that are primarily clinical in nature or that fail to make connections to the basic science issues of membrane structure, chemistry and function, are not appropriate for the journal. In a similar way, studies that are primarily descriptive and narratives of assays in a clinical or population study are best published in other journals. If you are not certain, it is entirely appropriate to write to us to inquire if your study is a good fit for the journal.