Efficacy and safety of Ginkgo biloba extract as an adjuvant in the treatment of Chinese patients with sudden hearing loss: a meta-analysis.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2023-12-01 DOI:10.1080/13880209.2023.2190782

Chao Yuan, Huan Zhang, Cuicui Sun, Kai Zhang

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Abstract

Context: Ginkgo biloba Linn (Ginkgoaceae) [leaves extract (GBE)] is authorized for the treatment of sudden hearing loss (SHL); however, its clinical feasibility in SHL has not been thoroughly investigated.

Objective: To evaluate the efficacy and safety of adjuvant GBE in the treatment of SHL.

Materials and methods: We used PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang, Chinese Scientific Journal Database, China Biomedical Database for literature research, starting from inception to 30 June 2022. The key terms: Ginkgo biloba extract, Sudden Sensorineural Deafness. This meta-analysis contained randomized controlled trials that compared the safety and efficacy of the combination of GBE and general treatments (GT) with GT alone for SHL. The extracted data were analyzed using Revman5.4 software with risk ratio (RR), 95% confidence intervals (CI) and mean difference (MD).

Results: Our meta-analysis included 27 articles with a total of 2623 patients. The results revealed that the effects of GBE adjuvant therapy was superior than GT (total effective rate: RR = 1.22, 95% CI: 1.18-1.26, p < 0.00001), the pure tone hearing threshold (MD = 12.29, 95% CI: 11.74-12.85, p < 0.00001) and hemorheology indexes (whole blood high shear viscosity: MD = 1.46, 95% CI: 0.47-2.44, p = 0.004) after treatment were significantly improved compared to non-treatment, while there was no significant difference as for hematocrit (red blood cells) (MD = 4.15, 95% CI: -7.15-15.45, p = 0.47).

Conclusion: The efficacy of GBE + GT for the treatment of SHL may be more promising than GT alone.

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银杏叶提取物辅助治疗突发性听力损失的疗效和安全性:一项meta分析。

背景：银杏叶提取物被授权用于治疗突发性听力损失；然而，其在SHL中的临床可行性尚未得到彻底的研究。目的：评价GBE辅助治疗SHL的有效性和安全性。材料和方法：从成立到2022年6月30日，我们使用PubMed、EMBASE、Web of Science、Cochrane Library、中国国家知识基础设施、万方、中国科学期刊数据库、中国生物医学数据库进行文献研究。关键词：银杏叶提取物，突发性感觉神经性耳聋。这项荟萃分析包含随机对照试验，比较了GBE和普通治疗（GT）与单独GT联合治疗SHL的安全性和有效性。使用Revman5.4软件对提取的数据进行风险比（RR）、95%置信区间（CI）和平均差（MD）分析。结果：我们的荟萃分析包括27篇文章，共2623名患者。结果显示，GBE辅助治疗的疗效优于GT（总有效率：RR=1.22，95%CI:1.18-1.26，p MD = 12.29，95%置信区间：11.74-12.85，p MD = 1.46，95%可信区间：0.47-2.44，p = 0.004）与未治疗组相比有显著改善，而红细胞压积（红细胞）（MD = 4.15，95%置信区间：-71.15-15.45，p = 0.47）。结论：GBE的疗效 + GT治疗SHL可能比单独使用GT更有前景。

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