{"title":"Anaplastic diffuse large B-cell lymphoma: a deceptive morphology.","authors":"Priyadharshini Sivasubramaniam, Aishwarya Ravindran","doi":"10.5045/br.2023.2022247","DOIUrl":null,"url":null,"abstract":"An elderly male without significant past medical history presented with cervical lymphadenopathy. Labs showed anemia (Hb 7.6 g/dL) and elevated WBC count (16×10 9 /L) with neutrophilia. Limited core biopsy revealed partial nodal involvement by an overtly malignant proliferation with marked anaplasia including multinucleated forms (A, B) and appeared to display a somewhat cohesive pattern of growth suggestive of an epithelioid neoplasm. Flow cytometry showed no immunophenotypic evidence of lymphoma. The primary differential diagnosis based on these findings included a poorly-differentiated carcinoma versus melanoma, however, immunostains for keratin, Melan A and SOX10 were negative. CD45 was only performed subsequently due to receipt of the case for hematopathologist evaluation given the lymphadenopathy. Surprisingly, the anaplastic tumor cells (A ×40; B ×200; C ×400) were diffusely CD45-positive; subsequent immunostains revealed positivity","PeriodicalId":46224,"journal":{"name":"Blood Research","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/7b/br-58-1-1.PMC10063593.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5045/br.2023.2022247","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
An elderly male without significant past medical history presented with cervical lymphadenopathy. Labs showed anemia (Hb 7.6 g/dL) and elevated WBC count (16×10 9 /L) with neutrophilia. Limited core biopsy revealed partial nodal involvement by an overtly malignant proliferation with marked anaplasia including multinucleated forms (A, B) and appeared to display a somewhat cohesive pattern of growth suggestive of an epithelioid neoplasm. Flow cytometry showed no immunophenotypic evidence of lymphoma. The primary differential diagnosis based on these findings included a poorly-differentiated carcinoma versus melanoma, however, immunostains for keratin, Melan A and SOX10 were negative. CD45 was only performed subsequently due to receipt of the case for hematopathologist evaluation given the lymphadenopathy. Surprisingly, the anaplastic tumor cells (A ×40; B ×200; C ×400) were diffusely CD45-positive; subsequent immunostains revealed positivity