Nephrotoxicity induced by natural compounds from herbal medicines - a challenge for clinical application.

IF 5.7 2区医学 Q1 TOXICOLOGY Critical Reviews in Toxicology Pub Date : 2022-10-01 DOI:10.1080/10408444.2023.2168178

Jinqiu Rao, Ting Peng, Na Li, Yuan Wang, Caiqin Yan, Kai Wang, Feng Qiu

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引用次数: 2

Abstract

Herbal medicines (HMs) have long been considered safe and effective without serious toxic and side effects. With the continuous use of HMs, more and more attention has been paid to adverse reactions and toxic events, especially the nephrotoxicity caused by natural compounds in HMs. The composition of HMs is complex and various, especially the mechanism of toxic components has been a difficult and hot topic. This review comprehensively summarizes the kidney toxicity characterization and mechanism of nephrotoxic natural compounds (organic acids, alkaloids, glycosides, terpenoids, phenylpropanoids, flavonoids, anthraquinones, cytotoxic proteins, and minerals) from different sources. Recommendations for the prevention and treatment of HMs-induced kidney injury were provided. In vitro and in vivo models for evaluating nephrotoxicity and the latest biomarkers are also included in this investigation. More broadly, this review may provide theoretical basis for safety evaluation and further comprehensive development and utilization of HMs in the future.

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草药天然化合物引起的肾毒性——临床应用的挑战。

草药(HMs)长期以来被认为是安全有效的，没有严重的毒副作用。随着中药的不断使用，其不良反应和毒性事件，尤其是中药中天然化合物引起的肾毒性问题越来越受到人们的关注。中药成分复杂多样，特别是毒性成分的作用机制一直是中药研究的难点和热点。本文综述了不同来源的天然肾毒性化合物(有机酸、生物碱、苷类、萜类、苯丙类、黄酮类、蒽醌类、细胞毒性蛋白和矿物质)的肾毒性特征和机制。并对hms所致肾损伤的防治提出了建议。本研究还包括用于评估肾毒性的体外和体内模型以及最新的生物标志物。本综述可为今后中药的安全性评价和进一步综合开发利用提供理论依据。

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来源期刊

Critical Reviews in Toxicology 医学-毒理学

CiteScore

9.50

自引率

1.70%

发文量

期刊介绍： Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.