Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-11-16 DOI:10.1017/erm.2022.38
Wei Feng Low, Yun Fong Ngeow, Jack Bee Chook, Kok Keng Tee, Seng-Kai Ong, Suat Cheng Peh, Jan Jin Bong, Rosmawati Mohamed
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Abstract

Hepatitis B virus (HBV) infection led to 66% liver deaths world-wide in year 2015. Thirty-seven per cent of these deaths were the result of chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Although early diagnosis of HCC improves survival, early detection is rare. Methylation of HBV DNA including covalently closed circular DNA (cccDNA) is more often encountered in HCC cases than those in CHB and cirrhosis. Three typical CpG islands within the HBV genome are the common sites for methylation. The HBV cccDNA methylation affects the viral replication and protein expression in the course of infection and may associate with the disease pathogenesis and HCC development. We review the current findings in HBV DNA methylation that provide insights into its role in HCC diagnosis.

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乙型肝炎病毒DNA甲基化及其在慢性乙型肝炎中的潜在作用
2015年,乙型肝炎病毒(HBV)感染导致全球66%的肝脏死亡。其中37%的死亡是慢性乙型肝炎(CHB)相关肝细胞癌(HCC)的结果。虽然肝癌的早期诊断可以提高生存率,但早期发现是罕见的。HBV DNA包括共价闭合环DNA (cccDNA)的甲基化在HCC病例中比在CHB和肝硬化病例中更常见。HBV基因组中三个典型的CpG岛是甲基化的常见位点。HBV cccDNA甲基化在感染过程中影响病毒复制和蛋白表达,可能与疾病的发病机制和HCC的发展有关。我们回顾了目前在HBV DNA甲基化方面的发现,为其在HCC诊断中的作用提供了见解。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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