Non-alcoholic Fatty Liver Disease in Children.

IF 2.8 3区医学 Q2 PERIPHERAL VASCULAR DISEASE Current vascular pharmacology Pub Date : 2023-01-01 DOI:10.2174/1570161121666221118155136

Emir Muzurović, Stergios Polyzos, Dimitri Mikhailidis, Sanja Borozan, Dušanka Novosel, Oleg Cmiljanić, Nataša Kadić, Christos Mantzoros

引用次数: 5

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the paediatric age. The growing prevalence of NAFLD and its advanced phenotype, non-alcoholic steatohepatitis (NASH), in children and adolescents parallels similar trends in obesity and type 2 diabetes mellitus. This trend may have serious long-term implications, including hepatic and extra-hepatic morbidity and mortality, the latter being related mostly due to cardiovascular disease and malignancies. This narrative review, which included 236 articles, summarizes current evidence on paediatric NAFLD, including pathophysiology, risk factors, complications, prevention and treatment (existing and emerging). Early recognition of NAFLD followed by timely and adequate management seems to be important on an individual basis. A global "call to action" regarding paediatric NAFLD seems appropriate to mitigate the burden of this disease.

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儿童非酒精性脂肪性肝病

非酒精性脂肪性肝病(NAFLD)已成为儿科最常见的肝脏疾病。在儿童和青少年中，NAFLD及其晚期表型非酒精性脂肪性肝炎(NASH)的流行率不断上升，与肥胖和2型糖尿病的流行趋势相似。这一趋势可能产生严重的长期影响，包括肝脏和肝外的发病率和死亡率，后者主要与心血管疾病和恶性肿瘤有关。这篇叙述性综述包括236篇文章，总结了目前关于儿科NAFLD的证据，包括病理生理学、危险因素、并发症、预防和治疗(现有和新出现的)。对NAFLD的早期识别以及及时和适当的治疗似乎对个人很重要。针对儿科NAFLD的全球“行动呼吁”似乎是适当的，以减轻这种疾病的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).