Insulin resistance relates to DKA severity and affects insulin requirement in children with type 1 diabetes at onset.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Pediatric Diabetes Pub Date : 2022-12-01 DOI:10.1111/pedi.13424

Concetta Mastromauro, Nella Polidori, Annalisa Blasetti, Laura Comegna, Francesco Chiarelli, Angelika Mohn, Cosimo Giannini

引用次数: 0

Abstract

Fluid and insulin treatments are the cornerstones of DKA management and indications on dosages are available. However, according to possible confounding factors, relevant data are still required to explain the different insulin dosages adopted at diabetes onset, particularly based upon insulin sensitivity.

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胰岛素抵抗与DKA严重程度有关，并影响发病时1型糖尿病儿童的胰岛素需求。

背景:液体和胰岛素治疗是DKA管理的基础，剂量的适应症是可用的。然而，根据可能的混杂因素，仍然需要相关数据来解释糖尿病发病时采用的不同胰岛素剂量，特别是基于胰岛素敏感性的胰岛素剂量。目的:探讨DKA的严重程度是否与不同的胰岛素敏感性状态有关，从而导致糖尿病发病时不同的胰岛素需要量。方法:回顾性分析62例新诊断的1型糖尿病合并DKA患儿的住院资料。人群分为三组:重度、中度和轻度DKA。分析人体测量、实验室测试、胰岛素和葡萄糖给药数据。计算葡萄糖输注率(GIR)、胰岛素输注率(IIR)、胰岛素输注率/胰岛素输注率(GIR /IIR)作为胰岛素敏感性指标。计算胰岛素和葡萄糖输注的曲线下面积(AUC)。结果:在三组中，重度至轻度DKA组的IIR降低，GIR和GIR/IIR升高(均p)。结论:重度DKA患者的胰岛素需求高于轻度DKA患者。根据DKA的严重程度，可能会记录胰岛素敏感性方面的显着差异，这可能导致新发1型糖尿病儿童量身定制胰岛素pH需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Diabetes 医学-内分泌学与代谢

CiteScore

6.60

自引率

14.70%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.