Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Upsala journal of medical sciences Pub Date : 2023-01-01 DOI:10.48101/ujms.v128.9194

Sofia Vikman, Anders Larsson, Måns Thulin, Torbjörn Karlsson

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Abstract

Background: Increased local angiogenesis is important for the growth and dissemination of cancer. The myeloproliferative neoplasm essential thrombocythemia (ET) is known to involve increased bone marrow angiogenesis. Blood levels of several angiogenesis-related proteins are increased in different types of cancer. The aim of this study was to investigate whether a subset of such proteins was elevated in treatment-naïve ET patients.

Methods: Blood plasma from 41 ET patients and 43 healthy aged-matched controls was analyzed for eight different angiogenesis-related proteins.

Results: The ET cohort displayed a more homogenous expression pattern of these proteins compared with controls. Five of the eight proteins were significantly increased in ET patients.

Conclusion: Increased plasma levels of matrix metallopeptidase 9 (MMP9) and endostatin have not previously been reported in ET. In our patients, MMP9 levels correlated positively with Janus kinase 2 (JAK2) V617F allele burden and leukocyte count.

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原发性血小板增多症患者血管生成相关血浆蛋白亚群水平升高。

背景:局部血管生成的增加是肿瘤生长和扩散的重要因素。骨髓增生性肿瘤原发性血小板增多症(ET)与骨髓血管生成增加有关。几种血管生成相关蛋白的血液水平在不同类型的癌症中升高。本研究的目的是调查treatment-naïve ET患者中是否有这类蛋白的一个亚群升高。方法:分析41例ET患者和43例年龄匹配的健康对照者的血浆中8种不同的血管生成相关蛋白。结果:与对照组相比，ET队列显示这些蛋白的表达模式更为均匀。在ET患者中，8种蛋白中的5种显著增加。结论:基质金属肽酶9 (MMP9)和内皮抑素血浆水平升高在ET中未见报道。在我们的患者中，MMP9水平与Janus kinase 2 (JAK2) V617F等位基因负荷和白细胞计数呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Upsala journal of medical sciences 医学-医学：内科

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Upsala Journal of Medical Sciences is published for the Upsala Medical Society. It has been published since 1865 and is one of the oldest medical journals in Sweden. The journal publishes clinical and experimental original works in the medical field. Although focusing on regional issues, the journal always welcomes contributions from outside Sweden. Specially extended issues are published occasionally, dealing with special topics, congress proceedings and academic dissertations.