Role of Serum Soluble Interleukin-2 Receptor Level in the Diagnosis of Sarcoidosis: A Systematic Review and Meta-Analysis.

IF 1.4 4区医学 Q4 RESPIRATORY SYSTEM Sarcoidosis, Vasculitis, and Diffuse Lung Diseases Pub Date : 2023-03-28 DOI:10.36141/svdld.v40i1.13499

Samiksha Gupta, Miloni Parmar, Rana Prathap Padappayil, Agam Bansal, Salim Daouk

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Abstract

Background and aim: Serum Soluble Interleukin-2 Receptor (sIL-2R) levels are used clinically as a disease activity marker for systemic sarcoidosis. Studies have investigated the diagnostic role of serum soluble interleukin-2 receptor (sIL-2R) level for sarcoidosis relative to biopsy. We performed a systematic review and meta-analysis of studies evaluating the diagnostic utility of sIL-2R.

Methods: We carried out an electronic search in Medline, Embase, Google Scholar, and Cochrane databases using keyword and Medical Subject Heading (MeSH) terms: sarcoidosis and sIL-2R. Studies evaluating the sIL-2R levels as a diagnostic tool in clinically diagnosed or biopsy-proven sarcoidosis patients compared to control groups with non-sarcoidosis patients were included. Forest plots were constructed using a random effect model depicting pooled sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy.

Results: We selected ten studies comprising 1477 patients, with 592 in the sarcoidosis group and 885 in the non- sarcoidosis group. Pooled sensitivity and specificity of sIL-2R levels were 0.88 (95% CI: 0.75-0.95) and 0.87 (95% CI 0.73-0.94) respectively. Pooled negative predictive value and positive predictive value were 0.91 (95% CI 0.77-0.97) and 0.85 (95% CI 0.59-0.96) respectively with diagnostic accuracy of 0.86 (95% CI 0.71- 0.93).

Conclusion: In addition to its utility as a marker of sarcoidosis disease activity, sIL-2R has high diagnostic accuracy. Despite the limitations of the heterogenous sarcoidosis population and different sIL-2R cutoffs, our results suggest that sIL-2R is an important biomarker that can be used to confirm sarcoidosis diagnosis in unconfirmed or unclear cases.

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血清可溶性白介素-2受体水平在结节病诊断中的作用:一项系统综述和荟萃分析。

背景与目的:血清可溶性白介素-2受体(sIL-2R)水平在临床上被用作系统性结节病的疾病活动性标志物。研究探讨了血清可溶性白介素-2受体(sIL-2R)水平相对于活检对结节病的诊断作用。我们对评估sIL-2R诊断效用的研究进行了系统回顾和荟萃分析。方法:在Medline、Embase、Google Scholar和Cochrane数据库中使用关键词和医学主题词(MeSH):结节病和sIL-2R进行电子检索。将sIL-2R水平作为临床诊断或活检证实的结节病患者的诊断工具，与非结节病患者的对照组进行比较。使用随机效应模型构建森林图，该模型描述了汇总的敏感性、特异性、阳性和阴性预测值以及诊断准确性。结果:我们选择了10项研究，包括1477例患者，其中结节病组592例，非结节病组885例。sIL-2R水平的综合敏感性和特异性分别为0.88 (95% CI: 0.75-0.95)和0.87 (95% CI: 0.73-0.94)。合并阴性预测值和阳性预测值分别为0.91 (95% CI 0.77 ~ 0.97)和0.85 (95% CI 0.59 ~ 0.96)，诊断准确率为0.86 (95% CI 0.71 ~ 0.93)。结论:sIL-2R除了作为结节病活动性的标志物外，还具有较高的诊断准确性。尽管存在异质性结节病人群和不同sIL-2R截止点的局限性，但我们的研究结果表明，sIL-2R是一个重要的生物标志物，可用于在未确诊或不明病例中确认结节病的诊断。

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来源期刊

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases 医学-呼吸系统

CiteScore

2.20

自引率

6.20%

发文量

期刊介绍： Sarcoidosis Vasculitis and Diffuse Lung Disease is a quarterly journal founded in 1984 by G. Rizzato. Now directed by R. Baughman (Cincinnati), P. Rottoli (Siena) and S. Tomassetti (Forlì), is the oldest and most prestigious Italian journal in such field.