Hemispherotomy in an infant with hemimegalencephaly and Ohtahara syndrome.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 Epub Date: 2023-04-18 DOI:10.1007/s10354-023-01009-5
Katarina Pavičić Klancir, Dubravko Habek, Vlasta Đuranović, Ana Tripalo Batoš, Sanja Pejić Roško, Milan Stanojević
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Abstract

We represent the case of a premature twin neonate born from uncomplicated pregnancy who developed seizures at the age of 24 h. Two-dimensional ultrasound and magnetic resonance imaging revealed left-sided hemimegalencephaly. Further extensive diagnostic evaluation revealed a diagnosis of Ohtahara syndrome. Resistance of the seizures to antiepileptic therapy led to hemispherotomy that was performed at the age of 10 months. Our patient is now a 4-year-old child, walking, eating without a nasogastric tube, still with right hemiparesis and lateral strabismus but without seizures.

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半球切除术治疗患有巨脑症和大田原综合征的婴儿。
二维超声波和磁共振成像显示患儿左侧大脑半球畸形。进一步的广泛诊断评估显示其诊断为大田原综合征。由于癫痫发作对抗癫痫治疗产生抗药性,医生在患者10个月大时为其实施了半球切除术。患者现在已经 4 岁了,可以行走,不用鼻胃管进食,仍然患有右侧偏瘫和侧斜视,但没有癫痫发作。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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