Drosophila collagens in specialised extracellular matrices.

IF 2.9 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biological Chemistry Pub Date : 2023-04-25 DOI:10.1515/hsz-2022-0297
Marcel Reinhardt, Maik Drechsler, Achim Paululat
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引用次数: 1

Abstract

The basement membrane (BM) constitutes a specialised form of the extracellular matrix (ECM) and plays important roles in many biological processes, such as cell migration, organ and tissue integrity, cell polarity, and the formation of metastases. In metazoans, a canonical BM is formed by only a few conserved structural core proteins: Laminin, Collagen IV, Nidogen and Perlecan. Depending on the tissue's function and mechanical load, additional matrix proteins interact with, or are incorporated into the BM, resulting in tissue-specific mechanical properties, such as higher stiffness or elasticity, or special resistance to mechanical stress or harmful environmental conditions. In flies, the collagen IV-like protein Pericardin forms an integral constituent of matrices around the heart and tension sensors (chordotonal organs) of the peripheral nervous system. The function and integrity of both organ systems strongly relies on the appropriate establishment of a Pericardin (Prc) matrix and the function of its adapter protein-Lonely heart (Loh). In this review, we provide an overview of the four collagens present in flies, and will discuss our recent work on the formation and function of Pericardin-containing matrices, the role of the adapter protein Lonely heart and the necessity of specialised ECM molecules in tissue architecture and function.

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果蝇胶原蛋白在专门的细胞外基质。
基底膜(BM)是细胞外基质(ECM)的一种特殊形式,在许多生物过程中起着重要作用,如细胞迁移、器官和组织完整性、细胞极性和转移的形成。在后生动物中,典型的骨髓基质仅由少数保守的结构核心蛋白组成:层粘连蛋白、胶原IV、Nidogen和Perlecan。根据组织的功能和机械负荷,额外的基质蛋白与基质相互作用,或被纳入基质,从而产生组织特异性的机械性能,如更高的刚度或弹性,或对机械应力或有害环境条件的特殊抵抗。在果蝇中,胶原iv样蛋白心包蛋白是周围神经系统心脏和张力传感器(弦缩器官)周围基质的组成部分。这两个器官系统的功能和完整性在很大程度上依赖于心包蛋白(Prc)基质的适当建立及其适配蛋白- lonely heart (Loh)的功能。在这篇综述中,我们概述了苍蝇中存在的四种胶原,并将讨论我们最近在含pericardin基质的形成和功能,适配器蛋白Lonely heart的作用以及专门的ECM分子在组织结构和功能中的必要性方面的工作。
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来源期刊
Biological Chemistry
Biological Chemistry 生物-生化与分子生物学
CiteScore
7.20
自引率
0.00%
发文量
63
审稿时长
4-8 weeks
期刊介绍: Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.
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