Fecal Calprotectin and Cow's Milk-Related-Symptoms Score in Children with Cow's Milk Protein Allergy.

IF 1.3 Q3 PEDIATRICS Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2023-01-01 DOI:10.5223/pghn.2023.26.1.43

Sahar Zain-Alabedeen, Noha Kamel, Mona Amin, Angharad Vernon-Roberts, Andrew S Day, Abdelmoneim Khashana

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引用次数: 2

Abstract

Purpose: The cow's milk-related-symptom-score (CoMiSS) tool was developed as an awareness tool for the assessment of cow's milk-related symptoms in infants or children. Fecal calprotectin (FC) is a noninvasive biomarker of gut inflammation that can be measured in serum and stool. This study aimed to investigate the relationship between FC levels and CoMiSS scores in infants with cow's milk protein allergy.

Methods: Infants (aged 6-12 months) who were allergic to cow's milk protein were enrolled prospectively. Following completion of the CoMiSS scoring, the infants were divided into group 1 (positive CoMiSS scores ≥12) and group 2 (negative CoMiSS scores <12). FC was measured using immunoassay.

Results: Of the 120 infants enrolled in this study, 60 (50.0%) had positive CoMiSS scores (group 1), while 60 (50.0%) had negative scores (group 2). The mean FC level was higher in the infants in group 1 than those in group 2 (2,934.57 µg/g vs. 955.13 µg/g; p<0.001). In addition, there was a positive correlation between FC and CoMiSS scores (R=0.168, p<0.0001). A FC level of 1,700 µg/g provided a sensitivity of 98.3%, specificity of 93.3%, and accuracy of 95.8% for the diagnosis of cow's milk protein allergy (CMPA).

Conclusion: FC measurement may have a role in the assessing infants with CMPA.

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牛奶蛋白过敏儿童粪便钙保护蛋白与牛奶相关症状评分

目的:开发牛奶相关症状评分(CoMiSS)工具，作为评估婴儿或儿童牛奶相关症状的意识工具。粪钙保护蛋白(FC)是一种无创的肠道炎症生物标志物，可以在血清和粪便中测量。本研究旨在探讨牛奶蛋白过敏婴儿FC水平与CoMiSS评分之间的关系。方法:前瞻性招募对牛奶蛋白过敏的婴儿(6-12个月)。CoMiSS评分完成后，将婴儿分为1组(CoMiSS阳性评分≥12)和2组(CoMiSS阴性评分)结果:本研究纳入的120例婴儿中，60例(50.0%)为CoMiSS阳性评分(1组)，60例(50.0%)为CoMiSS阴性评分(2组)。1组婴儿的平均FC水平高于2组(2934.57µg/g vs 955.13µg/g;结论:FC测量对CMPA患儿有一定的评价价值。

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来源期刊

Pediatric Gastroenterology, Hepatology & Nutrition PEDIATRICS-

CiteScore

3.90

自引率

0.00%

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期刊介绍： Pediatric Gastroenterology, Hepatology and Nutrition (Pediatr Gastroenterol Hepatol Nutr), an official journal of The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition, is issued bimonthly and published in English. The aim of Pediatr Gastroenterol Hepatol Nutr is to advance scientific knowledge and promote child healthcare by publishing high-quality empirical and theoretical studies and providing a recently updated knowledge to those practitioners and scholars in the field of pediatric gastroenterology, hepatology and nutrition. Pediatr Gastroenterol Hepatol Nutr publishes review articles, original articles, and case reports. All of the submitted papers are peer-reviewed. The journal covers basic and clinical researches on molecular and cellular biology, pathophysiology, epidemiology, diagnosis, and treatment of all aspects of pediatric gastrointestinal diseases and nutritional health problems.