Donepezil-Induced Complex Multimodal Hallucinations: Two Cases and a Review of the Literature.

IF 0.6 Q4 CLINICAL NEUROLOGY Case Reports in Neurology Pub Date : 2022-09-01 DOI:10.1159/000526159
Federico Emanuele Pozzi, Lucio Tremolizzo, Carlo Ferrarese, Ildebrando Appollonio
{"title":"Donepezil-Induced Complex Multimodal Hallucinations: Two Cases and a Review of the Literature.","authors":"Federico Emanuele Pozzi,&nbsp;Lucio Tremolizzo,&nbsp;Carlo Ferrarese,&nbsp;Ildebrando Appollonio","doi":"10.1159/000526159","DOIUrl":null,"url":null,"abstract":"<p><p>Hallucinations are common in neurodegenerative dementias, being present in a significant proportion of patients. Most of the available studies show that acetylcholinesterase inhibitors may be beneficial in preventing and treating hallucinations in patients with neurodegenerative and even psychiatric disorders, even though there are reports that they might also develop as an adverse effect of such therapy. However, a clear causal relationship for the latter association was not previously established. Here we describe 2 cases of patients treated with donepezil who developed complex multimodal hallucinations, which could be causally linked to the drug by means of a challenge-dechallenge (and rechallenge in one case) paradigm. We also provide a narrative review of the literature regarding donepezil and hallucinations and propose a hypothesis to explain the occurrence of this phenomenon.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"359-365"},"PeriodicalIF":0.6000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/63/crn-0014-0359.PMC9941780.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000526159","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Hallucinations are common in neurodegenerative dementias, being present in a significant proportion of patients. Most of the available studies show that acetylcholinesterase inhibitors may be beneficial in preventing and treating hallucinations in patients with neurodegenerative and even psychiatric disorders, even though there are reports that they might also develop as an adverse effect of such therapy. However, a clear causal relationship for the latter association was not previously established. Here we describe 2 cases of patients treated with donepezil who developed complex multimodal hallucinations, which could be causally linked to the drug by means of a challenge-dechallenge (and rechallenge in one case) paradigm. We also provide a narrative review of the literature regarding donepezil and hallucinations and propose a hypothesis to explain the occurrence of this phenomenon.

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
多奈哌齐致复杂多模态幻觉:两例及文献复习。
幻觉在神经退行性痴呆中很常见,在很大比例的患者中存在。大多数现有的研究表明,乙酰胆碱酯酶抑制剂在预防和治疗神经退行性疾病甚至精神疾病患者的幻觉方面可能是有益的,尽管有报道称它们也可能成为这种治疗的不利影响。然而,后一种关联的明确因果关系之前并没有建立。在这里,我们描述了2例使用多奈哌齐治疗的患者,他们出现了复杂的多模态幻觉,这可能与药物有因果关系,通过挑战-挑战(在一个病例中是再挑战)范式。我们也提供了关于多奈哌齐和幻觉的文献的叙述回顾,并提出了一个假设来解释这种现象的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Case Reports in Neurology
Case Reports in Neurology Medicine-Neurology (clinical)
CiteScore
1.50
自引率
0.00%
发文量
67
审稿时长
14 weeks
期刊介绍: This new peer-reviewed online-only journal publishes original case reports covering the entire spectrum of neurology. Clinicians and researchers are given a tool to disseminate their personal experience to a wider public as well as to review interesting cases encountered by colleagues all over the world. To complement the contributions supplementary material is welcomed. The reports are searchable according to the key words supplied by the authors; it will thus be possible to search across the entire growing collection of case reports with universally used terms, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.
期刊最新文献
COVID-19-Related Spinal Subdural Hematoma Presented with Acute Compressive Myelopathy with a Review of the Literature. Virus-Induced Voracity: Uncovering Hyperphagia Post-Herpes Simplex Virus Type 1. A Rare Case of Capnocytophaga canimorsus Meningitis in an Immunocompetent Patient: A Successful Outcome with a Short Course of Antibiotics. Periodic Paralysis: A Case Series with a Literature Review. Suspected Postpartum Depression Revealed to be CSF1R-Related Leukoencephalopathy: A Case Report.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1