In silico analysis of ACE2 from different animal species provides new insights into SARS-CoV-2 species spillover.

IF 2.1 4区医学 Q3 VIROLOGY Future Virology Pub Date : 2023-03-01 DOI:10.2217/fvl-2022-0187

Felipe Pantoja Mesquita, Pedro Filho Noronha Souza, Dyane Rocha Aragão, Expedito Maia Diógenes, Emerson Lucena da Silva, Jackson Lima Amaral, Valder Nogueira Freire, Débora de Souza Collares Maia Castelo-Branco, Raquel Carvalho Montenegro

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引用次数: 1

Abstract

Aim: This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. Materials & methods: The phylogenetic construction and molecular interactions were assessed using computational models. Results & conclusion: Despite the evolutionary distance, 11 species had a perfect fit for the interaction between their ACE2 and SARS-CoV-2 RBD (Chinchilla lanigera, Neovison vison, Rhinolophus sinicus, Emballonura alecto, Saccopteryx bilineata, Numida meleagris). Among them, the avian N. meleagris was reported for the first time in this study as a probable SARS-CoV-2 host due to the strong molecular interactions. Therefore, predicting potential hosts for SARS-CoV-2 for understanding the epidemiological cycle and proposal of surveillance strategies.

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不同动物物种ACE2的计算机分析为SARS-CoV-2物种溢出提供了新的见解。

目的:分析人与其他动物ACE2的系统发育关系，探讨不同物种SARS-CoV-2 RBD与ACE2的潜在相互作用。材料与方法:使用计算模型评估系统发育结构和分子相互作用。结果与结论:尽管进化距离较远，但11个物种(Chinchilla lanigera, Neovison vison, Rhinolophus sinicus, Emballonura alecto, Saccopteryx bilineata, Numida meleagris)的ACE2与SARS-CoV-2 RBD的相互作用完全吻合。其中，禽类N. meleagris因具有较强的分子相互作用，在本研究中首次被报道为可能的SARS-CoV-2宿主。因此，预测SARS-CoV-2的潜在宿主有助于了解流行病学周期并提出监测策略。

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.